Xu Han, Samuel R Cramer, Dennis C Y Chan, Nanyin Zhang
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引用次数: 0
Abstract
Memory is a complex brain process that requires coordinated activities in a large-scale brain network. However, the relationship between coordinated brain network activities and memory-related behavior is not well understood. In this study, we investigated this issue by suppressing the activity in the dorsal hippocampus (dHP) using chemogenetics and measuring the corresponding changes in brain-wide resting-state functional connectivity (RSFC) and memory behavior in awake rats. We identified an extended brain network contributing to the performance in a spatial memory related task. Our results were cross-validated using two different chemogenetic actuators, clozapine (CLZ) and clozapine-N-oxide (CNO). This study provides a brain network interpretation of memory performance, indicating that memory is associated with coordinated brain-wide neural activities.
记忆是一个复杂的大脑过程，需要在一个大规模的大脑网络中协调活动。然而，协调大脑网络活动与记忆相关行为之间的关系尚未得到很好的理解。在本研究中，我们利用化学遗传学的方法，通过抑制背侧海马（dHP）的活动，并测量清醒大鼠全脑静息状态功能连接（RSFC）和记忆行为的相应变化，来探讨这一问题。我们发现一个扩展的大脑网络有助于空间记忆相关任务的表现。使用两种不同的化学致动剂氯氮平（CLZ）和氯氮平- n -氧化物（CNO）对我们的结果进行了交叉验证。这项研究提供了记忆表现的大脑网络解释，表明记忆与协调的全脑神经活动有关。
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