Rabab Fouad, Bothaina Madkour, Manal Zahran, Ali Abdel Rahim, Dalia Salem, Omar Nassar, Shereen Elnashar, Ola Mahmoud
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引用次数: 0
Abstract
Background: The Tie2/Ang pathway was found to be involved in forming tumor blood vessels in various tumors. The goal of this study was to evaluate the value of Tie2/Ang pathway as a novel biomarkers for the early detection of chronic hepatitis C virus (CHC)-related hepatocellular carcinoma (HCC). And the possibility of their future application in HCC treatment.
Methods: Flow cytometry was performed to identify and count Tie2 expressing monocytes (TEMs) in peripheral blood monocytes from HCC patients (n = 25), CHC cirrhotic patients (n = 25) and healthy volunteers (n = 25). In addition, Angiopoietin 1 and 2 (Ang) levels in the serum were determined by enzyme linked immunosorbent assay (ELIZA).
Results: Percentage of TEMs in peripheral blood monocytes, serum Ang2 levels and Ang2/Ang1 ratio significantly increased in HCC patients compared with CHC patients and healthy controls (P< 0.001). However significant increase was only noticed in serum Ang1 levels in HCC group compared to the control group (P <0.05).
Conclusions: TEMs may promote angiogenesis in HCC regarding the Ang2/Tie2 signal pathway. Percentage of TEMs in peripheral blood monocytes, Ang2 serum levels and Ang2/Ang1 ratio may be applied as a biomarkers for identifying CHC-related HCC. Moreover, inhibiting the proangiogenic functions of this pathway may represent a promising strategy to improve the efficacy of current treatments for HCC.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
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