{"title":"Synthetic diffusion-weighted imaging in prostate cancer diagnosis: a comparison study with different B-value combinations.","authors":"L He, Z Zhang, J Zhang, J Xia, Y Wang, J Zhu","doi":"10.1016/j.crad.2024.106770","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the impact of different b-value combinations on synthetic diffusion-weighted imaging (sDWI) and determine the sDWI with an optimal b-value combination for prostatic cancer (PCa) diagnosis.</p><p><strong>Material and methods: </strong>A retrospective analysis of 68 patients with abnormal prostate-specific antigen (PSA) was conducted. The sDWI images with b value of 1500 s/mm<sup>2</sup> were separately reconstructed by the following five b-value combinations: b=0, 200s/mm<sup>2</sup> (sDWI<sub>0-200</sub>); b=600, 800s/mm<sup>2</sup> (sDWI<sub>600-800</sub>); b=0, 600s/mm<sup>2</sup> (sDWI<sub>0-600</sub>); b=200, 800s/mm<sup>2</sup> sDWI<sub>200-800</sub>); b=0, 800s/mm<sup>2</sup> (sDWI<sub>0-800</sub>). Quantitative analysis was performed on the acquired DWI (aDWI) images with b=1500s/mm<sup>2</sup> (aDWI<sub>1500</sub>) and all sDWI images. These six image groups were scored in five aspects for image quality and further reviewed by two radiologists via six protocols: Protocol Ⅰ, T<sub>2</sub>WI+sDWI<sub>0-200</sub>; Protocol Ⅱ, T<sub>2</sub>WI+sDWI<sub>600-800</sub>; Protocol Ⅲ, T<sub>2</sub>WI+sDWI<sub>0-600</sub>; Protocol Ⅳ, T<sub>2</sub>WI+sDWI<sub>200-800</sub>; Protocol Ⅴ, T<sub>2</sub>WI+sDWI<sub>0-800</sub>; Protocol Ⅵ, T<sub>2</sub>WI+aDWI<sub>1500</sub>. The corresponding diagnostic efficacies for PCa were evaluated using receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Contrast ratio values of all sDWI images were higher than those of aDWI<sub>1500</sub> images. Contrast-to-noise ratio values of sDWI<sub>0-200</sub> and sDWI<sub>600-800</sub> images were lower than those of the rest sDWI images. All subjective quality scores of sDWI<sub>0-600</sub>, sDWI<sub>200-800,</sub> and sDWI<sub>0-800</sub> were significantly higher than other groups except for background signal suppression. The area under the curve (AUC) of Protocol Ⅲ, Ⅳ, Ⅴ, and Ⅵ was significantly larger than those of other protocols.</p><p><strong>Conclusion: </strong>Different b-value combinations impact the image quality and diagnostic accuracy of sDWI for PCa detection. The combination of b≤200s/mm<sup>2</sup> and b≥600s/mm<sup>2</sup> revealed to be optimal.</p>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"81 ","pages":"106770"},"PeriodicalIF":2.1000,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.crad.2024.106770","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To evaluate the impact of different b-value combinations on synthetic diffusion-weighted imaging (sDWI) and determine the sDWI with an optimal b-value combination for prostatic cancer (PCa) diagnosis.
Material and methods: A retrospective analysis of 68 patients with abnormal prostate-specific antigen (PSA) was conducted. The sDWI images with b value of 1500 s/mm2 were separately reconstructed by the following five b-value combinations: b=0, 200s/mm2 (sDWI0-200); b=600, 800s/mm2 (sDWI600-800); b=0, 600s/mm2 (sDWI0-600); b=200, 800s/mm2 sDWI200-800); b=0, 800s/mm2 (sDWI0-800). Quantitative analysis was performed on the acquired DWI (aDWI) images with b=1500s/mm2 (aDWI1500) and all sDWI images. These six image groups were scored in five aspects for image quality and further reviewed by two radiologists via six protocols: Protocol Ⅰ, T2WI+sDWI0-200; Protocol Ⅱ, T2WI+sDWI600-800; Protocol Ⅲ, T2WI+sDWI0-600; Protocol Ⅳ, T2WI+sDWI200-800; Protocol Ⅴ, T2WI+sDWI0-800; Protocol Ⅵ, T2WI+aDWI1500. The corresponding diagnostic efficacies for PCa were evaluated using receiver operating characteristic (ROC) curves.
Results: Contrast ratio values of all sDWI images were higher than those of aDWI1500 images. Contrast-to-noise ratio values of sDWI0-200 and sDWI600-800 images were lower than those of the rest sDWI images. All subjective quality scores of sDWI0-600, sDWI200-800, and sDWI0-800 were significantly higher than other groups except for background signal suppression. The area under the curve (AUC) of Protocol Ⅲ, Ⅳ, Ⅴ, and Ⅵ was significantly larger than those of other protocols.
Conclusion: Different b-value combinations impact the image quality and diagnostic accuracy of sDWI for PCa detection. The combination of b≤200s/mm2 and b≥600s/mm2 revealed to be optimal.
期刊介绍:
Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including:
• Computed tomography
• Magnetic resonance imaging
• Ultrasonography
• Digital radiology
• Interventional radiology
• Radiography
• Nuclear medicine
Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.