Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM BMC Endocrine Disorders Pub Date : 2024-12-31 DOI:10.1186/s12902-024-01685-3

Magdy Mohamed Allam, Soha Magdy Ahmed, Dalia Khamis El-Deeb, Ahmed Yassin Bahgat, Ramy Mohamed Ghazy, Hanaa Tarek El-Zawawy

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Abstract

Background: Autoimmune thyroid diseases (AITD) and allergic rhinitis (AR) are prevalent conditions; however, limited research has investigated their association. This study aimed to evaluate whether AR can be considered a risk factor for developing AITD.

Methods: A retrospective cohort study analyzed the records of AITD patients who visited Alexandria University Students Hospital between January 2017 and December 2021. The parameters included in the study were thyroid-stimulating hormone (TSH), Free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibodies (TPOAb), thyrotropin receptor antibody (TRAb), eosinophils count, and IgE.

Results: Out of 4,515 eligible patients, 41.7% were diagnosed with AR in addition to AITD. Among the patients with both conditions, 81% were females, their mean age was 45.71 ± 24.14 years, and the mean duration of AITD was 7.32 ± 2.11 years. The Kaplan-Meier analysis revealed that the AR cohort had a higher cumulative incidence of AITD than did the non-AR cohort (log-rank test, p = 0.001). Multivariate-adjusted hazardous ratios showed that patients with AR, female sex, higher white blood cell count, and diagnosis in November had a higher risk of developing AITD.

Conclusions: Screening for AITD should be conducted at the time of diagnosis of AR as it could be a risk factor for AITD.

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埃及患者变应性鼻炎与自身免疫性甲状腺疾病发展之间的关系

背景：自身免疫性甲状腺疾病（AITD）和变应性鼻炎（AR）是常见的疾病；然而，有限的研究调查了它们之间的联系。本研究旨在评估AR是否可被视为发生AITD的危险因素。方法：回顾性队列研究分析2017年1月至2021年12月在亚历山大大学学生医院就诊的AITD患者的记录。研究参数包括促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、甲状腺过氧化物酶抗体（TPOAb）、促甲状腺素受体抗体（TRAb）、嗜酸性粒细胞计数、IgE。结果：在4515名符合条件的患者中，41.7%被诊断为AR和AITD。两种情况的患者中女性占81%，平均年龄45.71±24.14岁，平均AITD病程7.32±2.11年。Kaplan-Meier分析显示，AR组的AITD累积发病率高于非AR组（log-rank检验，p = 0.001）。多变量校正危险比显示，患有AR、女性、白细胞计数较高、11月诊断的患者发生AITD的风险较高。结论：在诊断AR时应筛查AITD，因为它可能是AITD的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.