Serum metabolomics and lipoproteomics discriminate celiac disease and non-celiac gluten sensitivity patients

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS Clinical nutrition Pub Date : 2025-02-01 DOI:10.1016/j.clnu.2024.12.016

Alessia Vignoli , Claudio Luchinat , Nicola Segata , Daniela Renzi , Leonardo Tenori , Antonino Salvatore Calabrò

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Abstract

Background&aims

Celiac disease (CD) and potential CD (pCD) are immune-mediated disorders triggered by the ingestion of gluten. In non-celiac gluten sensitivity (NCGS) neither allergic nor autoimmune mechanisms are involved. Relationships between NCGS and CD need to be further investigated.

Methods

Serum metabolomics and lipoproteomics, performed via nuclear magnetic resonance spectroscopy, were used to characterize these three gluten-related disorders. Lasso regression models were calculated to discriminate the groups of interest.

Results

Several metabolites and lipoprotein-related parameters (particularly those associated with HDL cholesterol) allowed the selective discrimination between CD (and pCD) and NCGS. This evidence pointed to possible alterations of the gut microbiota in NCGS patients. Cross-validated regression models were able to discriminate between CD and NCGS, and pCD and NCGS with AUCs of 0.90 and 0.83, respectively.

Conclusion

This pilot study suggests changes in the gut microbiota and paves the way to the elucidation of the underlying mechanisms of NCGS.

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血清代谢组学和脂蛋白组学区分乳糜泻和非乳糜泻麸质敏感患者。

背景与目的：乳糜泻（CD）和潜在的乳糜泻（pCD）是由摄入谷蛋白引起的免疫介导的疾病。在非乳糜泻麸质敏感性（NCGS）中，既不涉及过敏机制，也不涉及自身免疫机制。NCGS与CD之间的关系有待进一步研究。方法：通过核磁共振波谱进行血清代谢组学和脂蛋白组学，对这三种麸质相关疾病进行表征。计算Lasso回归模型来区分感兴趣的组。结果：几种代谢物和脂蛋白相关参数（特别是与HDL胆固醇相关的参数）允许CD（和pCD）和NCGS之间的选择性区分。这一证据表明NCGS患者肠道微生物群可能发生改变。交叉验证的回归模型能够区分CD和NCGS， pCD和NCGS， auc分别为0.90和0.83。结论：本初步研究提示了肠道菌群的变化，为阐明NCGS的潜在机制铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.