WALINET: A water and lipid identification convolutional neural network for nuisance signal removal in 1 H $$ {}^1\mathrm{H} $$ MR spectroscopic imaging

Abstract

Purpose

Proton magnetic resonance spectroscopic imaging (${\hspace{0.17em}}^{1}H$-MRSI) provides noninvasive spectral-spatial mapping of metabolism. However, long-standing problems in whole-brain ${\hspace{0.17em}}^{1}H$-MRSI are spectral overlap of metabolite peaks with large lipid signal from scalp, and overwhelming water signal that distorts spectra. Fast and effective methods are needed for high-resolution ${\hspace{0.17em}}^{1}H$-MRSI to accurately remove lipid and water signals while preserving the metabolite signal. The potential of supervised neural networks for this task remains unexplored, despite their success for other MRSI processing.

Methods

We introduce a deep learning method based on a modified Y-NET network for water and lipid removal in whole-brain ${\hspace{0.17em}}^{1}H$-MRSI. The WALINET (WAter and LIpid neural NETwork) was compared with conventional methods such as the state-of-the-art lipid L2 regularization and Hankel–Lanczos singular value decomposition (HLSVD) water suppression. Methods were evaluated on simulated models and in vivo whole-brain MRSI using NMRSE, SNR, CRLB, and FWHM metrics.

Results

WALINET is significantly faster and needs 8s for high-resolution whole-brain MRSI, compared with 42min for conventional HLSVD+L2. WALINET suppresses lipid and water in the brain by 25–45 and 34–53-fold, respectively. WALINET has better performance than HLSVD+L2, providing: (1) more lipid removal with 41% lower NRMSE; (2) better metabolite signal preservation with 71% lower NRMSE in simulated data; 155% higher SNR and 50% lower CRLB in in vivo data. Metabolic maps obtained by WALINET in healthy subjects and patients show better gray-/white-matter contrast with more visible structural details.

Conclusions

WALINET has superior performance for nuisance signal removal and metabolite quantification on whole-brain ${\hspace{0.17em}}^{1}H$-MRSI compared with conventional state-of-the-art techniques. This represents a new application of deep learning for MRSI processing, with potential for automated high-throughput workflow.