Research advances in the construction of stem cell-derived ovarian organoids.

IF 7.3 2区 医学 Q1 CELL & TISSUE ENGINEERING Stem Cell Research & Therapy Pub Date : 2024-12-31 DOI:10.1186/s13287-024-04122-3
Tianyue Zhang, Mengtong Zhang, Sichen Zhang, Shaowei Wang
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Abstract

Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and improving treatments, which benefits women's health. Constructing ovarian organoids involves two main processes: differentiating induced pluripotent stem cells (iPSCs) into germ and ovarian somatic cells to restore ovarian function and using extracellular matrix (ECM) to create a suitable ovarian microenvironment and scaffold. Although the technology is still in its early stages, future advancements will likely involve integrating high-throughput analysis, 3D-printed scaffolds, and efficient iPSC induction, driving progress in reproductive and regenerative medicine.

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干细胞衍生卵巢类器官构建的研究进展。
卵巢类器官在女性生殖医学中是必不可少的,它增强了我们对卵巢疾病的了解,改善了治疗方法,这有利于女性的健康。卵巢类器官的构建主要包括两个过程:诱导多能干细胞(iPSCs)分化为生殖细胞和卵巢体细胞,恢复卵巢功能;利用细胞外基质(ECM)构建合适的卵巢微环境和支架。尽管该技术仍处于早期阶段,但未来的进展可能包括整合高通量分析、3d打印支架和高效的iPSC诱导,从而推动生殖和再生医学的进步。
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来源期刊
Stem Cell Research & Therapy
Stem Cell Research & Therapy CELL BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
13.20
自引率
8.00%
发文量
525
审稿时长
1 months
期刊介绍: Stem Cell Research & Therapy serves as a leading platform for translational research in stem cell therapies. This international, peer-reviewed journal publishes high-quality open-access research articles, with a focus on basic, translational, and clinical research in stem cell therapeutics and regenerative therapies. Coverage includes animal models and clinical trials. Additionally, the journal offers reviews, viewpoints, commentaries, and reports.
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