Total Serum Immunoglobulin E in a Cohort of Children with Food Allergy.

IF 8.2 1区医学 Q1 ALLERGY Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-12-28 DOI:10.1016/j.jaip.2024.12.029

Amal H Assa'ad, Lili Ding, Qing Duan, Tesfaye B Mersha, Christopher Warren, Lucy Bilaver, Megan Ulrich, Mark Wlodarski, Jialing Jiang, Johnathan J Choi, Susan S Xie, Ashwin Kulkarni, Susan Fox, Sai Nimmagadda, Mary C Tobin, Mahboobeh Mahdavinia, Hemant Sharma, Ruchi S Gupta

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Abstract

Background: Total serum immunoglobulin E (TsIgE) has not been examined in children with food allergy.

Objective: Evaluate associations of TsIgE with patient, household, environmental and community-level characteristics among children with food allergy.

Method: Linear mixed effect models of data from 398 Black and/or African American (B/AA) and White and/or European American (W/EA) children with allergist-diagnosed food allergy from the multi-center, observational cohort FORWARD; TsIgE in kU/L was the primary outcome measure.

Results: In univariable analyses of data from all study sites, children's TsIgE was positively associated with older age (p < .001), B/AA race (p < .001), male sex (p = .014), lower household income (p = .005), lower caregiver education (p = .005), higher area deprivation index (p< .001), presence of allergic rhinitis (p < .001), asthma (p < .001), and eczema (p = .024), and a higher number of food allergies (p< .001), but not with tobacco smoke exposure. With covariable adjustment in multivariable analysis, total serum IgE was higher in older vs. younger children (p < .001), male vs. female children, B/AA vs. W/EA children (p < .001), and in children with allergic rhinitis (p = .010), asthma (p < .001), eczema (p = .007), or a higher number of food allergies (p < .001), but not with tobacco smoke exposure or area deprivation index.

Conclusions: In children with food allergy, age, sex, race, atopic diagnosis, allergic rhinitis, asthma and eczema are associated with TsIgE. These findings are important when TsIgE values are utilized in diagnosis and therapies.

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食物过敏儿童队列的血清总免疫球蛋白E。

背景：尚未对食物过敏儿童的总血清免疫球蛋白 E（TsIgE）进行检测：尚未对食物过敏儿童的血清总免疫球蛋白 E (TsIgE) 进行研究：评估食物过敏儿童的 TsIgE 与患者、家庭、环境和社区特征之间的关联：对多中心观察队列 FORWARD 中 398 名经过敏专科医生确诊为食物过敏的黑人和/或非裔美国人（B/AA）儿童以及白人和/或欧洲裔美国人（W/EA）儿童的数据进行线性混合效应模型分析；以 kU/L 为单位的 TsIgE 是主要的结果测量指标：在对所有研究地点的数据进行的单变量分析中，儿童的 TsIgE 与以下因素呈正相关：年龄较大（p < .001）、B/AA 种族（p < .001）、男性（p = .014）、家庭收入较低（p = .005）、照顾者受教育程度较低（p = .005）、较高的地区贫困指数（p< .001）、过敏性鼻炎（p < .001）、哮喘（p < .001）和湿疹（p = .024）以及较多的食物过敏（p < .001），但与烟草烟雾暴露无关。在多变量分析中进行协变量调整后，年龄较大儿童与年龄较小儿童（p < .001）、男性儿童与女性儿童、B/AA 儿童与 W/EA 儿童（p < .001）以及患有过敏性鼻炎（p = .010）、哮喘（p < .001）、湿疹（p = .007）或食物过敏次数较多（p < .001）的儿童的血清总 IgE 较高，但与烟草烟雾暴露或地区贫困指数无关：结论：在食物过敏儿童中，年龄、性别、种族、特应性诊断、过敏性鼻炎、哮喘和湿疹与 TsIgE 相关。这些发现对于利用 TsIgE 值进行诊断和治疗非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Allergy and Clinical Immunology-In Practice ALLERGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

11.10

自引率

9.60%

发文量

683

审稿时长

50 days

期刊介绍： JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases. This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders. The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.