Cross-sectional area on magnetic resonance images of the semitendinosus tendon is strongly related to the collagen fibril diameter

IF 2 Q2 ORTHOPEDICS Journal of Experimental Orthopaedics Pub Date : 2024-12-30 DOI:10.1002/jeo2.70124

Yushin Mizuno, Junsuke Nakase, Tatsuya Ishikawa, Kazuki Asai, Yasushi Takata, Tomoyuki Kanayama, Takuya Sengoku, Noriyuki Ozaki, Hiroyuki Tsuchiya

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Abstract

Purpose

Using a thin semitendinosus tendon as an autograft is a risk factor for poor clinical outcomes after anterior cruciate ligament reconstruction. Preoperative evaluation of the cross-sectional area of the semitendinosus tendon using magnetic resonance imaging is useful. However, studies comparing the cross-sectional area of the semitendinosus tendon on magnetic resonance imaging and the collagen fibril diameter of the semitendinosus tendon are lacking. We aimed to investigate the relationship between collagen fibril diameter and cross-sectional area of the semitendinosus tendon using magnetic resonance imaging.

Methods

We included 14 patients (24.5 ± 12.3 years) who underwent anterior cruciate or medial patellofemoral ligament reconstruction using the semitendinosus tendon. Samples not used to prepare autografts were used to evaluate the collagen fibril diameter. Transmission electron microscopy was used to measure several hundred short fibril diameters per sample. Magnetic resonance imaging (T2-weighted imaging) was used to assess the cross-sectional area of the semitendinosus tendon, measured 8 cm proximal to the tibial attachment. Spearman's rank correlation coefficients were determined for collagen fibril diameter and cross-sectional area of the semitendinosus tendon on magnetic resonance imaging, and the relationship between both parameters was evaluated.

Results

The collagen fibril diameter of the semitendinosus tendon was calculated from 10,279 fibrils. The correlation coefficient between the collagen fibril diameter and the cross-sectional area of the semitendinosus tendon was 0.821 (p < 0.001).

Conclusions

A strong positive correlation was observed between the collagen fibril diameter and cross-sectional area of the semitendinosus tendon. A small cross-sectional area on the magnetic resonance image of the semitendinosus tendon indicated a thin collagen fibril diameter, which may affect the mechanical strength of the autograft for anterior cruciate ligament reconstruction. The collagen fibril diameter can be predicted preoperatively by measuring the cross-sectional area of the semitendinosus tendon using magnetic resonance imaging.

Level of Evidence

Level IV.

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半腱肌腱的磁共振图像截面积与胶原纤维直径密切相关。

目的：使用薄半腱肌腱作为自体移植物是前交叉韧带重建后临床预后不佳的危险因素。术前评估半腱肌腱的横截面积使用磁共振成像是有用的。然而，比较半腱肌腱在磁共振成像上的横截面积和半腱肌腱胶原纤维直径的研究缺乏。我们的目的是探讨胶原纤维直径与半腱肌腱横截面积的磁共振成像的关系。方法：我们纳入了14例（24.5±12.3岁）采用半腱肌腱重建髌股前交叉韧带或髌股内侧韧带。未用于制备自体移植物的样品用于评估胶原纤维直径。利用透射电子显微镜测量每个样品的数百个短纤维直径。使用磁共振成像（t2加权成像）评估半腱肌腱的横截面积，测量胫骨附着体近端8厘米。确定磁共振成像中胶原纤维直径与半腱肌腱横截面积的Spearman等级相关系数，并评价两者之间的关系。结果：从10279根原纤维中计算出半腱肌腱的胶原纤维直径。胶原纤维直径与半腱肌腱横截面积的相关系数为0.821 (p)。结论：胶原纤维直径与半腱肌腱横截面积呈正相关。半腱肌腱的磁共振图像截面积小，显示胶原纤维直径较细，这可能会影响前交叉韧带重建自体移植物的机械强度。术前可通过磁共振成像测量半腱肌腱的横截面积来预测胶原纤维直径。证据等级：四级。

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