Outcomes of Radical Radiotherapy (RT) or Chemoradiotherapy (CRT) in Surgically Inoperable Advanced Oral Cavity Cancer: A Single Center Experience.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-12-31 DOI:10.1002/hed.28055

Shashank Shenoy, Ankita Mallick, Sudipta Pati, Sanjoy Chatterjee, Indranil Mallick

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Abstract

Background: Patients with locally advanced, surgically unresectable oral squamous cell cancers (SU-OSCC) are often treated with palliative intent. There is limited information on the outcomes of radical intent treatment with radiotherapy (RT) or chemoradiotherapy (CRT).

Methods: We retrospectively examined patients with Stage III/IV previously untreated SU-OSCC treated definitively from 2011 to 2021 in a single institution with RT or CRT with or without neoadjuvant chemotherapy (NACT).

Results: Sixty-nine patients met the inclusion criteria. Oral tongue (38%) and buccal mucosa (32%) were the commonest subsites. T4a, T4b, and N2-3 disease were present in 28 (40.6%), 26 (37.7%), and 39 (56.5%) patients, respectively. Median OS and PFS of the whole group were 16 months and 10 months. The 2-year loco-regional control was 60.4%. Bone involvement or NACT use did not affect outcomes.

Conclusions: Upfront radical RT/CRT in patients with SU-OSCC with good performance status results in good outcomes and should be preferred to a palliative approach.

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根治性放疗（RT）或放化疗（CRT）治疗不能手术的晚期口腔癌的结果：单中心经验。

背景：局部晚期，手术不能切除的口腔鳞状细胞癌（SU-OSCC）患者通常以姑息治疗为目的。关于放疗（RT）或放化疗（CRT）的根治性治疗结果的信息有限。方法：我们回顾性研究了2011年至2021年在单一机构接受RT或CRT治疗或不接受新辅助化疗（NACT）的III/IV期未治疗的SU-OSCC患者。结果：69例患者符合纳入标准。口腔舌（38%）和颊黏膜（32%）是最常见的亚位点。T4a、T4b和N2-3病变分别为28例（40.6%）、26例（37.7%）和39例（56.5%）。全组中位OS和PFS分别为16个月和10个月。2年局部-区域控制率为60.4%。骨受累或使用NACT对结果没有影响。结论：对于表现良好的SU-OSCC患者，术前根治性RT/CRT治疗效果良好，应优先于姑息治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.

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