Correlates of neurocognitive performance in older adults with chronic pain and negative emotions: baseline data from the problem adaptation therapy for pain (PATH-pain) randomized controlled trial.

Abstract

Chronic pain is highly prevalent among older adults, is associated with cognitive deficits, and is commonly treated in primary care. We sought to document the extent of impairment across specific neurocognitive domains and its correlates among older adults with chronic pain in primary care. We analyzed baseline data from the Problem Adaptation Therapy for Pain trial, which examined a psychosocial intervention to improve emotion regulation in 100 adults ≥ 60 years with comorbid chronic pain and negative emotions, who did not have evidence of moderate-to-severe cognitive impairment. Questionnaires on comorbidities, depressive symptoms, pain intensity, and pain-related disability were administered along with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Montreal Cognitive Assessment (MoCA). Multiple regression assessed the relationship between demographic and clinical characteristics with specific neurocognitive domains. Over half of participants (56%) had mild-to-moderate cognitive impairment (<26 on the MoCA). Across domains, participants scored the lowest in visuospatial/constructional (M = 86.2; SD = 15.7), and 15%-23% scored at least one standard deviation below the mean for immediate and delayed memory, visuospatial/constructional, and attention. In adjusted models, greater medical comorbidities were associated with poorer performance on the total RBANS, immediate memory, and attention. Cognitive deficits in older adults with chronic pain in primary care are substantial, with varying levels of deficits by neurocognitive domain. Future research should examine synergistic effects of chronic pain and comorbidities on cognition, and the impact of cognitive deficits on older adults' ability to engage in pain interventions and self-management behaviors.