A Doped Surface Ionization Method for Ion Mobility Spectrometry

IF 1.8 3区化学 Q4 BIOCHEMICAL RESEARCH METHODS Rapid Communications in Mass Spectrometry Pub Date : 2024-12-30 DOI:10.1002/rcm.9974

Jianhua Lin, Xiaoguang Gao, Jian Jia, Xiuli He

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Abstract

Rationale

Exhaled breath can be used for early warning of disease, with organic nitrogen compounds, including triethylamine (TEA), being linked to various medical conditions. Surface ionization ion mobility spectrometry (SI-IMS) facilitates the direct detection of TEA in exhaled breath. However, the presence of multiple ionization products of TEA poses challenges for both quantitative and qualitative analyses.

Methods

A doped surface ionization (DSI) method consisting of surface ionization of dopants and gas-phase reaction of samples was proposed, and TEA was detected when combined with an ion mobility spectrometer. TEA at different concentrations and spiked by human breath was detected to evaluate the method's properties.

Results

TEA with concentrations from 5.99 to 30.50 ppb and a relative humidity of 80% was detected. The peak intensity of the protonated TEA ions demonstrated a linear correlation with concentration, yielding a fitted correlation coefficient of R² = 0.94. A standard deviation less than 0.066% was obtained with 10 replicate analyses of 29.92 ppb TEA, and the recovery rate of the sample was 93.57%.

Conclusions

The SI-IMS based on the DSI method has the advantages of excellent selective ionization, high accuracy and sensitivity, and remarkable repeatability for detecting TEA. It is a promising method for detecting specific organic nitrogen compounds in exhaled breath.

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离子迁移率光谱的掺杂表面电离方法。

理由：呼出的气体可用于疾病的早期预警，包括三乙胺（TEA）在内的有机氮化合物与各种疾病有关。表面电离离子迁移谱法（SI-IMS）有助于直接检测呼出气体中的TEA。然而，TEA的多种电离产物的存在给定量和定性分析带来了挑战。方法：提出了掺杂剂表面电离与样品气相反应相结合的掺杂表面电离（DSI）方法，并结合离子迁移谱仪检测TEA。对不同浓度的TEA进行检测，并通过人的呼吸对其进行加峰，以评价该方法的性能。结果：检测到的TEA浓度为5.99 ~ 30.50 ppb，相对湿度为80%。质子化TEA离子的峰强度与浓度呈线性相关，拟合相关系数R2 = 0.94。在29.92 ppb TEA的浓度下进行10次重复分析，其标准偏差小于0.066%，样品回收率为93.57%。结论：基于DSI法的SI-IMS检测TEA具有选择性电离性好、准确度和灵敏度高、重复性好等优点。这是一种很有前途的检测呼出气体中特定有机氮化合物的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rapid Communications in Mass Spectrometry 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

219

审稿时长

2.6 months

期刊介绍： Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.