Lipoprotein(a) as a Predictor of Nonalcoholic Fatty Liver After Pancreatectomy.

IF 1.6 4区医学 Q4 ONCOLOGY Anticancer research Pub Date : 2025-01-01 DOI:10.21873/anticanres.17416

Kyohei Abe, Shuichi Fujioka, Yuki Takano, Yoshihiro Shirai, Masashi Tsunematsu, Michinori Matsumoto, Kenei Furukawa, Koichiro Haruki, Shinji Onda, Toru Ikegami

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Abstract

Background/aim: Lipoprotein(a) (Lp(a)) is a complex protein involved in the transport of insoluble lipids in plasma. Its expression is predominantly genetically determined, with 70% to over 90% influenced by the number of Kringle IV type 2 domains. This study investigated the association between preoperative serum Lp(a) level and development of post-pancreatectomy nonalcoholic fatty liver disease (NAFLD) in patients who underwent pancreatectomy.

Patients and methods: Serum Lp(a) level was measured preoperatively and retrospectively evaluated together with other known risk factors for NAFLD, which was defined using a computed tomography-based Hounsfield unit (HU) value for liver parenchyma below 40 HU at the anteroposterior midpoint.

Results: NAFLD developed after pancreatectomy in 40 patients (17.5%) in the high Lp(a)-group, which was significantly lower compared to the 30 patients (53%) in the low Lp(a)-group (p=0.01). There were no other significant background factors related to preoperative Lp (a) level. Multivariate analysis indicated that low Lp(a) level is an independent risk factor for postoperative NAFLD, as well as pancreatic head resection, a small residual pancreatic volume, poor intake of pancrelipase, and postoperative diarrhea.

Conclusion: NAFLD after pancreatectomy could be predicted preoperatively to a certain extent by examining serum Lp(a) level.

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预测胰腺切除术后非酒精性脂肪肝的脂蛋白（a）。

背景/目的：脂蛋白(a) （Lp(a)）是一种参与血浆中不溶性脂质运输的复杂蛋白。其表达主要由遗传决定，70%至90%以上受Kringle IV型2型结构域数量的影响。本研究探讨了胰切除术患者术前血清Lp(a)水平与胰切除术后非酒精性脂肪性肝病（NAFLD）发生的关系。患者和方法：术前测定血清Lp(a)水平，并与NAFLD的其他已知危险因素一起进行回顾性评估，使用基于计算机断层扫描的肝实质在前后中点低于40 HU的Hounsfield单位（HU）值来定义。结果：高Lp(a)组40例（17.5%）患者在胰切除术后发生NAFLD，显著低于低Lp(a)组30例（53%）（p=0.01）。没有其他与术前Lp (a)水平相关的显著背景因素。多因素分析显示，低Lp(a)水平是术后NAFLD的独立危险因素，胰头切除、胰腺残留体积小、胰酶摄入不足、术后腹泻也是NAFLD的独立危险因素。结论：术前检测血清Lp(a)水平可在一定程度上预测胰切除术后NAFLD的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.