Real-life dosing conditions in older adults and geriatric patients in Poland – An international questionnaire study to investigate the regional differences in drug intake behaviour in the older population

IF 4.3 3区 医学 Q1 PHARMACOLOGY & PHARMACY European Journal of Pharmaceutical Sciences Pub Date : 2024-12-30 DOI:10.1016/j.ejps.2024.107001
Dorota Sarwinska , Marta Miller , Jagoda Arendt , Michał Markiewicz , Katarzyna Michta , Michael Grimm , Łukasz Balwicki , Werner Weitschies
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Abstract

Older people represent approximately 20% of the Polish population and are the primary population using medications. Behaviours connected with drug intake (such as dosage form modifications, type and amount of fluid and/or food accompanying administration) are crucial for drug efficacy and avoidance of adverse effects. The presented study had three research aims; firstly, to investigate the real-life drug administration process among older adults and geriatric patients in Poland. Secondly, to compare data from Poland with data from a previous study performed in Germany, based on the same questionnaire. Thirdly, to discuss the potential influence of dosing conditions on the behaviour of orally administered medications (especially drug absorption) and identify potential problems with drug intake itself. This questionnaire-based study was conducted in the form of in-person interviews led by research team members. In this study, 174 participants, aged 65–94 years old were recruited from three settings in the Pomeranian region of Poland: home setting, nursing home and hospital. In Poland, the preferred method of medication intake was administration of all medications simultaneously. Patients were taking their medications most often directly after food ingestion, which commonly consisted of bread with butter, ham or cheese and black tea. The most common fluid for drug administration was either a few sips or 100 mL of non-carbonated water (mineral or tap water) as well as black tea. Dividing tablets (defined as splitting tablets in parts) was the most common modification. There were many similarities in the way of administering medications between the Polish and German older populations, specifically the use of non-carbonated water as the most common fluid for medication intake as well as bread as the main ingredient of breakfast and dinner. The biggest difference between populations was the choice of black tea as a medium for medication intake much more frequently in the Polish population than the German (who also preferred mint, herbal and fruit teas), and using a smaller volume of fluid. The presented study gives insight into the medication intake process in the older Polish population from the Pomeranian region in North Poland in comparison to the German population from the Pomeranian region in North East Germany. The results may help to identify factors that could decrease medication efficacy and safety, which is crucial, especially for the older population. Furthermore, the collected data may be useful for in vitro or in silico simulations to enhance drug development based on real-life data.

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波兰老年人和老年患者的真实给药条件——一项调查老年人口药物摄入行为地区差异的国际问卷研究。
老年人约占波兰人口的20%,是使用药物的主要人群。与药物摄入有关的行为(如剂型改变、随服液体和/或食物的种类和数量)对药物疗效和避免不良反应至关重要。本研究有三个研究目的;首先,调查波兰老年人和老年患者的现实用药过程。其次,将波兰的数据与先前在德国进行的基于相同问卷的研究的数据进行比较。第三,讨论给药条件对口服药物行为(特别是药物吸收)的潜在影响,并确定药物摄入本身的潜在问题。本研究以问卷调查为基础,由研究小组成员带领进行面对面访谈。在这项研究中,174名年龄在65-94岁的参与者从波兰波美拉尼亚地区的三个环境中招募:家庭环境、养老院和医院。在波兰,首选的药物摄入方法是同时服用所有药物。患者通常在食物摄入后直接服药,通常包括黄油面包、火腿或奶酪和红茶。最常见的给药液体是几口或100毫升的非碳酸水(矿泉水或自来水)以及红茶。将片剂分开(定义为将片剂分成几部分)是最常见的修改。波兰和德国老年人口的用药方式有许多相似之处,特别是使用非碳酸水作为最常见的药物摄入液体,以及面包作为早餐和晚餐的主要食材。人群之间最大的差异是,波兰人群比德国人更频繁地选择红茶作为药物摄入的媒介(德国人也喜欢薄荷茶、草药茶和水果茶),而且使用的液体量更小。本研究对波兰北部波美拉尼亚地区的老年波兰人口与德国东北部波美拉尼亚地区的德国人口的药物摄入过程进行了比较。研究结果可能有助于确定可能降低药物疗效和安全性的因素,这一点至关重要,尤其是对老年人而言。此外,收集的数据可能对体外或计算机模拟有用,以增强基于真实数据的药物开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.60
自引率
2.20%
发文量
248
审稿时长
50 days
期刊介绍: The journal publishes research articles, review articles and scientific commentaries on all aspects of the pharmaceutical sciences with emphasis on conceptual novelty and scientific quality. The Editors welcome articles in this multidisciplinary field, with a focus on topics relevant for drug discovery and development. More specifically, the Journal publishes reports on medicinal chemistry, pharmacology, drug absorption and metabolism, pharmacokinetics and pharmacodynamics, pharmaceutical and biomedical analysis, drug delivery (including gene delivery), drug targeting, pharmaceutical technology, pharmaceutical biotechnology and clinical drug evaluation. The journal will typically not give priority to manuscripts focusing primarily on organic synthesis, natural products, adaptation of analytical approaches, or discussions pertaining to drug policy making. Scientific commentaries and review articles are generally by invitation only or by consent of the Editors. Proceedings of scientific meetings may be published as special issues or supplements to the Journal.
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