Targeting protein modification: a new direction for immunotherapy of pancreatic cancer.

IF 10 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2025-01-01 DOI:10.7150/ijbs.101861
Xinyu Ge, Ke Zhang, Jie Zhu, Yuan Chen, Zhengwang Wang, Peng Wang, Peng Xu, Jie Yao
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Abstract

Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor transformation, cancer progression, and metastasis in pancreatic cancer. Additionally, advancements in tumor immunotherapy indicate that PTMs are essential in immune cell activation, transport, and energy metabolism. This study aimed to investigate the effects of different PTMs on immunotherapy for pancreatic cancer, providing new perspectives and suggesting directions for future research.

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靶向蛋白修饰:胰腺癌免疫治疗的新方向。
翻译后修饰(PTMs)通过将官能团共价附着在底物上,从而改变蛋白质的构象,影响其生物活性、作用机制和功能性能。PTMs及其相互作用对许多关键的信号转导过程至关重要,包括胰腺癌的肿瘤转化、癌症进展和转移。此外,肿瘤免疫治疗的进展表明,PTMs在免疫细胞激活、运输和能量代谢中至关重要。本研究旨在探讨不同PTMs对胰腺癌免疫治疗的影响,为未来的研究提供新的视角和方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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