⁶⁸Ga-DOTA-FAPI-04 and ¹⁸F-FDG PET/CT: a head-to-head comparison for peritoneal carcinomatosis diagnostic accuracy.

IF 2.3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Abdominal Radiology Pub Date : 2025-01-03 DOI:10.1007/s00261-024-04653-6

Xiaolin Chen, Xiao Pang, Yan Zhao, Xinming Zhao, Yunuan Liu, Fenglian Jing, Huiqing Yuan, Xiaoshan Chen, Tianyue Li, Yingchen Wang, Yali Liu, Jingya Han, Jingmian Zhang, Jianfang Wang, Zhaoqi Zhang

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Abstract

Purpose: The study aimed to compare the diagnostic accuracy of ⁶⁸Ga-DOTA-FAPI-04 (⁶⁸Ga-FAPI) and ¹⁸F-FDG PET/CT for peritoneal carcinomatosis (PC) in patients with various types of cancer.

Methods: The study enrolled 113 patients with suspected peritoneal malignancy, each of whom underwent ⁶⁸Ga-FAPI and ¹⁸F-FDG PET/CT scans. Lesions in all patients were confirmed through pathology or radiological follow-up. The evaluation and comparison of diagnostic performance, visual scores, maximum standardized uptake value (SUV_max), mean tumor-to-background ratio (TBR), and the peritoneal cancer index (PCI) score were conducted.

Results: Compared to ¹⁸F-FDG, ⁶⁸Ga-FAPI PET/CT presented higher sensitivity, negative predictive value, and accuracy for detecting PC on a patient-level (100% vs. 93.2%, 100% vs. 22.22% and 93.81% vs. 86.73%, respectively). Semi-quantitative evaluation revealed that ⁶⁸Ga-FAPI PET/CT had significantly higher SUV_max and TBR for PC [(6.06 ± 3.04 vs. 4.82 ± 2.75, P = 0.001) and (8.50 ± 5.01 vs. 2.92 ± 1.67, P < 0.001)]. The PCI_-FAPI score for PC was higher than the PCI_-FDG score (11.28 ± 7.10 vs. 5.69 ± 5.15, P < 0.001).

Conclusions: ⁶⁸Ga-FAPI has demonstrated superior diagnostic accuracy compared to ¹⁸F-FDG PET/CT in detecting PC with various types of cancer, particularly gastric cancer. Additionally, ⁶⁸Ga-FAPI has shown significantly higher uptake and PCI score in PC compared to ¹⁸F-FDG, indicating its potential importance in clinical.

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68Ga-DOTA-FAPI-04和18F-FDG PET/CT：对腹膜癌诊断准确性的正面比较

目的：比较68Ga-DOTA-FAPI-04 （68Ga-FAPI）与18F-FDG PET/CT对不同类型肿瘤腹膜癌（PC）的诊断准确性。方法：研究纳入113例疑似腹膜恶性肿瘤患者，每位患者均接受68Ga-FAPI和18F-FDG PET/CT扫描。所有患者的病变均通过病理或影像学随访得到证实。对诊断表现、视觉评分、最大标准化摄取值（SUVmax）、平均肿瘤与背景比（TBR）、腹膜癌指数（PCI）评分进行评价和比较。结果：与18F-FDG相比，68Ga-FAPI PET/CT在患者层面检测PC的灵敏度、阴性预测值和准确率分别为100%比93.2%、100%比22.22%和93.81%比86.73%。半定量评价显示，68Ga-FAPI PET/CT对PC的SUVmax和TBR均有显著提高[（6.06±3.04 vs. 4.82±2.75,P = 0.001）和(8.50±5.01 vs. 2.92±1.67，PC的P -FAPI评分高于PCI-FDG评分(11.28±7.10 vs. 5.69±5.15，P]]结论：68Ga-FAPI对不同类型肿瘤的PC，尤其是胃癌的诊断准确性优于18F-FDG PET/CT。此外，与18F-FDG相比，68Ga-FAPI在PC中的摄取和PCI评分明显更高，表明其在临床中的潜在重要性。

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来源期刊

Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.20

自引率

8.30%

发文量

334

期刊介绍： Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits