Primary tumor surgery in de novo metastatic breast cancer: Game-changer or misinterpretation?

IF 3.2 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Experimental Medicine Pub Date : 2025-01-03 DOI:10.1007/s10238-024-01552-4
Gianluca Franceschini
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Abstract

The study titled "Primary tumor surgery in patients with de novo metastatic breast cancer: a nationwide population-based retrospective cohort study in Belgium" opens an important discussion about the potential role of surgery in the treatment of de novo MBC; although the results are promising, they should be interpreted with caution given the limitations of the study design. The question remains whether surgery is truly a game-changer for all patients or whether its benefits are more nuanced depending on individual patient factors and disease characteristics. As the oncology community continues to explore this question, a modern breast surgeon should emphasize the importance of further prospective trials and personalized treatment strategies that consider not only surgery but also the growing arsenal of available systemic therapies.

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新发转移性乳腺癌的原发肿瘤手术:改变游戏规则还是误解?
这项名为“原发性肿瘤手术治疗新生转移性乳腺癌患者:比利时一项基于全国人群的回顾性队列研究”的研究开启了关于手术在新生转移性乳腺癌治疗中的潜在作用的重要讨论;虽然结果是有希望的,但考虑到研究设计的局限性,它们应该谨慎解释。问题仍然是手术是否真的改变了所有患者的游戏规则,或者它的好处是否取决于个体患者的因素和疾病特征。随着肿瘤学社区继续探索这个问题,现代乳房外科医生应该强调进一步的前瞻性试验和个性化治疗策略的重要性,不仅要考虑手术,还要考虑越来越多的可用的全身治疗方法。
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来源期刊
Clinical and Experimental Medicine
Clinical and Experimental Medicine 医学-医学:研究与实验
CiteScore
4.80
自引率
2.20%
发文量
159
审稿时长
2.5 months
期刊介绍: Clinical and Experimental Medicine (CEM) is a multidisciplinary journal that aims to be a forum of scientific excellence and information exchange in relation to the basic and clinical features of the following fields: hematology, onco-hematology, oncology, virology, immunology, and rheumatology. The journal publishes reviews and editorials, experimental and preclinical studies, translational research, prospectively designed clinical trials, and epidemiological studies. Papers containing new clinical or experimental data that are likely to contribute to changes in clinical practice or the way in which a disease is thought about will be given priority due to their immediate importance. Case reports will be accepted on an exceptional basis only, and their submission is discouraged. The major criteria for publication are clarity, scientific soundness, and advances in knowledge. In compliance with the overwhelmingly prevailing request by the international scientific community, and with respect for eco-compatibility issues, CEM is now published exclusively online.
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