Human ovarian tissue xenotransplantation: advancements, challenges, and future perspectives.

IF 6 1区医学 Q1 OBSTETRICS & GYNECOLOGY Human reproduction Pub Date : 2025-01-02 DOI:10.1093/humrep/deae291

Paweena Thuwanut, Ellen C R Leonel, Thalles Fernando Rocha Ruiz, Porntip Sirayapiwat, Stine Gry Kristensen, Christiani A Amorim

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Abstract

Ovarian tissue cryopreservation and transplantation has emerged as a promising fertility preservation technique for individuals facing premature ovarian insufficiency due to various medical conditions or treatments. Xenotransplantation, involving the transplantation of ovarian tissue into animal hosts, has played a pivotal role in refining ovarian tissue cryopreservation and transplantation techniques and addressing key challenges. This review provides a comprehensive overview of the current landscape of ovarian tissue xenotransplantation research, focusing on its applications in investigating ovarian biology, optimizing ovarian tissue cryopreservation and transplantation protocols, and assessing safety concerns. It also explores the utilization of xenografting of human ovarian tissue in mouse models in the last 10 years. Key findings from preclinical studies investigating grafting site optimization, cryopreservation protocol refinement, the development of strategies to mitigate chemotherapy-induced damage, follicle development, tissue revascularization, and the risk of malignant cell reintroduction are summarized. Moreover, the review examines the ethical considerations surrounding the use of animals in ovarian tissue xenotransplantation research and suggests emerging alternative models that aim to minimize animal use while maximizing clinical relevance.

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人类卵巢组织异种移植：进展、挑战和未来展望。

卵巢组织冷冻保存和移植已成为一种很有前途的生育保护技术，用于因各种医疗条件或治疗而面临卵巢功能不全的个体。异种卵巢移植是一种将卵巢组织移植到动物体内的技术，在完善卵巢组织冷冻保存和移植技术以及解决关键挑战方面发挥着关键作用。本文综述了卵巢组织异种移植研究的现状，重点介绍了其在卵巢生物学研究、优化卵巢组织冷冻保存和移植方案以及评估安全性方面的应用。它还探讨了近10年来人类卵巢组织异种移植在小鼠模型中的应用。本文总结了临床前研究的主要发现，包括移植部位优化、冷冻保存方案改进、减轻化疗诱导损伤的策略发展、卵泡发育、组织血运重建和恶性细胞再引入的风险。此外，该综述探讨了围绕在卵巢组织异种移植研究中使用动物的伦理考虑，并提出了旨在最大限度地减少动物使用同时最大化临床相关性的新兴替代模型。

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来源期刊

Human reproduction 医学-妇产科学

CiteScore

10.90

自引率

6.60%

发文量

1369

审稿时长

1 months

期刊介绍： Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues. Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.