Causal Association Between Endometriosis and Coronary Heart Disease: Evidence from the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis.

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Women's Health Pub Date : 2024-12-28 eCollection Date: 2024-01-01 DOI:10.2147/IJWH.S493708

Wenting Xu, Yanxing Huang, Ping Ji, Jiayu Wang, Jinfen Yu, Li Yang

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Abstract

Objective: Failure to resolve inflammation is a novel feature of angiogenic-dependent diseases such as endometriosis and atherosclerosis.The correlation and causality between endometriosis and coronary heart disease is unclear. Here, we investigated the correlation and causality between endometriosis and coronary heart disease.

Methods: The relevant data was extracted from the NHANES database (Year range: 1999-2006) and analyzed to determine the correlation between endometriosis and coronary heart disease using weighted multivariable logistic regression models. Mendelian randomization analysis was used to assess the causal relationship between endometriosis and coronary heart disease risk.

Results: We evaluated the data obtained from 3943 participants and did not observe any association between endometriosis and coronary heart disease in weighted multivariable logistic regression models (Model 1, OR: 1.85, 95% CI: 0.66-5.15, P: 0.23; Model 2, OR: 0.89, 95% CI: 0.30-2.62, P: 0.82; Model 3, OR: 0.61, 95% CI: 0.19-1.95, P: 0.38). Two-sample Mendelian randomization analysis did not reveal a causal relationship between endometriosis and coronary heart disease (OR: 1.00, 95% CI: 0.94-1.07, P: 0.882).

Conclusion: Our findings did not indicate any association or causal relationship between endometriosis and coronary heart disease.

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子宫内膜异位症与冠心病的因果关系：来自全国健康与营养调查和孟德尔随机化分析的证据。

目的：炎症消退失败是子宫内膜异位症和动脉粥样硬化等血管生成依赖性疾病的新特征。子宫内膜异位症与冠心病的相关性和因果关系尚不清楚。在此，我们研究了子宫内膜异位症与冠心病之间的相关性和因果关系。方法：从NHANES数据库（年份范围：1999-2006）中提取相关数据，采用加权多变量logistic回归模型进行分析，确定子宫内膜异位症与冠心病的相关性。孟德尔随机化分析用于评估子宫内膜异位症与冠心病风险之间的因果关系。结果：我们评估了来自3943名参与者的数据，在加权多变量logistic回归模型中未观察到子宫内膜异位症与冠心病之间的任何关联(模型1，OR: 1.85, 95% CI: 0.66-5.15, P: 0.23；模型2，OR: 0.89, 95% CI: 0.30-2.62, P: 0.82；模型3，OR: 0.61, 95% CI: 0.19-1.95, P: 0.38)。双样本孟德尔随机化分析未显示子宫内膜异位症与冠心病之间的因果关系（OR: 1.00, 95% CI: 0.94-1.07, P: 0.882）。结论：我们的研究结果表明子宫内膜异位症和冠心病之间没有任何关联或因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.