Causal Association Between Endometriosis and Coronary Heart Disease: Evidence from the National Health and Nutrition Examination Survey and Mendelian Randomization Analysis.

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Women's Health Pub Date : 2024-12-28 eCollection Date: 2024-01-01 DOI:10.2147/IJWH.S493708

Wenting Xu, Yanxing Huang, Ping Ji, Jiayu Wang, Jinfen Yu, Li Yang

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引用次数: 0

Abstract

Objective: Failure to resolve inflammation is a novel feature of angiogenic-dependent diseases such as endometriosis and atherosclerosis.The correlation and causality between endometriosis and coronary heart disease is unclear. Here, we investigated the correlation and causality between endometriosis and coronary heart disease.

Methods: The relevant data was extracted from the NHANES database (Year range: 1999-2006) and analyzed to determine the correlation between endometriosis and coronary heart disease using weighted multivariable logistic regression models. Mendelian randomization analysis was used to assess the causal relationship between endometriosis and coronary heart disease risk.

Results: We evaluated the data obtained from 3943 participants and did not observe any association between endometriosis and coronary heart disease in weighted multivariable logistic regression models (Model 1, OR: 1.85, 95% CI: 0.66-5.15, P: 0.23; Model 2, OR: 0.89, 95% CI: 0.30-2.62, P: 0.82; Model 3, OR: 0.61, 95% CI: 0.19-1.95, P: 0.38). Two-sample Mendelian randomization analysis did not reveal a causal relationship between endometriosis and coronary heart disease (OR: 1.00, 95% CI: 0.94-1.07, P: 0.882).

Conclusion: Our findings did not indicate any association or causal relationship between endometriosis and coronary heart disease.

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.