A Patient With Concurrent Hidradenitis Suppurativa and Porokeratosis Palmaris et Plantaris Disseminata: Case Report and Review of Autoinflammatory Keratinization Diseases.

IF 1.6 4区 医学 Q3 DERMATOLOGY Journal of Cutaneous Pathology Pub Date : 2025-01-03 DOI:10.1111/cup.14774
Meredith C Rogers, Mark Ash, Amanda Hernandez, Gregory A Hosler
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Abstract

The term autoinflammatory keratinization diseases (AIKDs) was recently proposed as a unifying concept for diseases characterized by inflammation in the epidermis and upper dermis which leads to hyperkeratosis, caused by genetic perturbations of the innate immune system. We present a case of a patient with hidradenitis suppurativa and porokeratosis, two AIKDs, followed by a review of these conditions as well as other AIKDs. This case was distinguished by hypertrophic porokeratoses involving cystic hair follicles, showing histopathologic features of both conditions within single biopsy specimens. The patient's course was additionally complicated by SCC arising within a porokeratosis. Our case demonstrates a rare overlap of two AIKDs, occurring not only within the same patient but also within the same lesions.

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并发化脓性汗腺炎和广布性掌跖角化孔症1例:自体炎症性角化病的病例报告和综述。
自体炎症性角化病(AIKDs)这个术语最近被提出作为一个统一的概念,用于描述由先天免疫系统的遗传扰动引起的表皮和真皮上部炎症导致角化过度的疾病。我们提出一个病例的患者与化脓性汗腺炎和角化孔症,两个AIKDs,随后审查这些条件以及其他AIKDs。该病例以累及囊性毛囊的肥厚性角化孔病为特征,在单个活检标本中表现出两种情况的组织病理学特征。患者的病程还因在骨质疏松症中出现的鳞状细胞癌而复杂化。我们的病例表现出罕见的两种AIKDs重叠,不仅发生在同一患者中,而且发生在同一病变中。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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