Longitudinal investigation of neuroimaging changes related to memory decline in multiple sclerosis: Testing a mechanistic model.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2025-02-01 Epub Date: 2025-01-03 DOI:10.1177/13524585241303491

Leila Simani, Ceren Tozlu, Seonjoo Lee, Jordan Dworkin, Alexander S Ratzan, Korhan Buyukturkoglu, Kaho Onomichi, Jennie Mata, Claire S Riley, Victoria M Leavitt

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Abstract

Background: Memory decline is common in multiple sclerosis (MS), although pathophysiological mechanisms are not fully understood.

Objective: The objective was to investigate the relationship of changes in structural and functional neuroimaging markers to memory decline over 3-year follow-up.

Methods: Participants with MS underwent cognitive evaluation and structural, diffusion, and functional 3T magnetic resonance imaging (MRI) scans at baseline and 3-year follow-up. Changes in neuroimaging metrics from baseline to follow-up were compared between memory stable and memory decline groups. Our hypothesis that structural and functional connectivity changes mediate the association of atrophy to memory decline was tested.

Results: A total of 249 MS patients completed baseline visit; 169 (67.8%) returned at 3-year follow-up. Based on ⩾10% decline, memory decline was observed in 44.4% (n = 75). Those with memory decline showed marginally greater whole-brain volume loss over time compared with those with stable memory performance (p = 0.08). In those with memory decline, changes in white matter tract integrity were related to regional cortical thinning (p < 0.01). Exploratory mediation analysis revealed structural and functional connectivity to mediate the relationship of atrophy to verbal and visual memory decline.

Conclusion: Further work is needed to characterize complex interrelationships of atrophy and structural/functional connectivity changes to memory decline in MS.

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与多发性硬化症记忆衰退相关的神经影像学变化的纵向研究：检验机制模型。

背景：记忆衰退在多发性硬化症（MS）中很常见，尽管病理生理机制尚不完全清楚。目的：通过3年的随访，探讨结构和功能神经影像学指标的变化与记忆衰退的关系。方法：MS患者在基线和3年随访期间接受认知评估和结构、扩散和功能3T磁共振成像（MRI）扫描。比较记忆稳定组和记忆衰退组从基线到随访期间神经影像学指标的变化。我们的假设，结构和功能连接的变化介导萎缩与记忆衰退的关联是经过测试的。结果：共有249例MS患者完成基线访视；3年随访返回169例（67.8%）。基于小于或等于10%的下降，观察到44.4%的记忆力下降（n = 75）。与记忆表现稳定的人相比，记忆衰退的人随着时间的推移显示出更大的全脑容量损失（p = 0.08）。记忆衰退患者脑白质束完整性变化与脑皮层区域变薄有关（p < 0.01）。探索性中介分析揭示了结构和功能连接介导萎缩与语言和视觉记忆衰退的关系。结论：需要进一步研究萎缩和结构/功能连接改变与MS记忆衰退的复杂相互关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585