Lijuan Yang, Ying Feng, Jianhua Xue, Jianguang Tian, Yunle Wang
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引用次数: 0
Abstract
Background: Obstructive sleep apnea has been associated with various urinary system diseases, including prostatic hyperplasia and nocturia. Recently, it has been linked to prostate cancer. This study investigated the relationship between the apnea hypopnea index, prostate-specific antigen (PSA) levels, and changes in PSA.
Methods: A total of 673 male patients who received portable sleep monitoring were assessed. All participants underwent thorough health assessments, including PSA testing. Individuals in Study 1 were divided into OSA and control groups based on an REI (Respiratory event index) ≥ 15 events/h. In Study 2, 176participants from the initial study were retested for PSA after three years.
Results: In Study 1, patients with OSA had significantly higher ln-transformed PSA levels than controls (P < 0.05). Ln-transformed PSA levels showed a positive correlation with the REI (r = 0.184, p = 0.015). In Study 2, after three years, the ln-transformed PSA level increased by 0.13 ng/ml in the OSA group, while it decreased by -0.05 ng/ml in the control group. The change in ln-transformed PSA was significantly higher in patients with OSA (p = 0.014). Even after adjusting for age, body mass index (BMI), smoking, hypertension, and diabetes, REI remained a significant predictor of PSA level changes (β = 0.226, 95% CI = 0.001-0.009; p = 0.008).
Conclusions: This study highlights the close relationship between REI and PSA levels in individuals with obstructive sleep apnea, indicating that REI is an independent risk factor for PSA levels. Obstructive sleep apnea may be associated with the incidence of prostate cancer.
期刊介绍：
The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep.
Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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