[The usefulness of therapeutic drug monitoring during treatment with second-generation antidepressants].

Q4 Medicine Tijdschrift voor psychiatrie Pub Date : 2024-01-01
K Catthoor, G Steegen, M De Hert, M Van Den Bossche, B Sabbe, T Dreesen, J Detraux
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引用次数: 0

Abstract

Background: Although there is clear evidence that therapeutic drug monitoring (TDM) has beneficial effects for patients treated with tricyclic antidepressants, it is generally not recommended for second-generation antidepressants (SGA). However, it has been suggested that methodological shortcomings might influence the results in TDM studies with SGA.

Aim: A qualitative assessment of randomized controlled trials (RCTs) that specifically investigated drug concentration-effect relationships of SGA in patients with major depressive disorder (MDD) to analyze the potential benefit of TDM during treatment with these agents.

Method: A literature search, using the PubMed, Embase, and Cochrane CENTRAL databases, was conducted for RCTs. A research protocol was used to make a quality assessment.

Results: A total of 15 studies were included. Evidence for the existence of a drug concentration-effect relationship during the administration of SGA in adult patients with MDD is virtually non-existent. The argument that methodological shortcomings might influence the results in TDM studies with SGA is weak.

Conclusion: There is little evidence that methodological shortcomings of studies would influence the results in TDM studies with SGA. This does not mean that TDM during treatment with SGA cannot be useful in specific situations.

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[第二代抗抑郁药治疗期间药物监测的有效性]。
背景:虽然有明确的证据表明,治疗性药物监测(TDM)对接受三环类抗抑郁药治疗的患者有有益的影响,但通常不推荐用于第二代抗抑郁药(SGA)。然而,有人认为方法学上的缺陷可能会影响使用SGA进行TDM研究的结果。目的:对专门研究重度抑郁障碍(MDD)患者中SGA药物浓度-效应关系的随机对照试验(RCTs)进行定性评估,以分析TDM在使用这些药物治疗期间的潜在益处。方法:使用PubMed、Embase和Cochrane CENTRAL数据库进行文献检索。采用研究方案进行质量评估。结果:共纳入15项研究。在成年重度抑郁症患者服用SGA期间存在药物浓度-效应关系的证据几乎不存在。认为方法上的缺陷可能会影响SGA的TDM研究结果的观点是站不住脚的。结论:几乎没有证据表明,研究方法上的缺陷会影响伴有SGA的TDM研究的结果。这并不意味着在SGA治疗期间TDM不能在特定情况下有用。
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来源期刊
Tijdschrift voor psychiatrie
Tijdschrift voor psychiatrie Medicine-Medicine (all)
CiteScore
0.60
自引率
0.00%
发文量
118
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