Annexin A1 expression in Lupus Nephritis.

Q3 Medicine Tunisie Medicale Pub Date : 2024-12-05 DOI:10.62438/tunismed.v102i12.5005

Fatma Dhaffouli, Hend Hachicha, Nesrine Elloumi, Raouia Fakhfakh, Sawsen Feki, Mohamed Ben Hmida, Tahya Sellami Boudawara, Khawla Kammoun, Hatem Masmoudi

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Abstract

Introduction: Lupus nephritis (LN) is an immune complex glomerulonephritis, caused by systemic lupus erythematosus. It is associated with an increase of morbidity and mortality. In LN, the immune responses dysregulation is one of the crucial pathogenic pathways. Annexin A1 (AnxA1), as an anti-inflammatory mediator, plays a critical role in immune responses, in addition to a variety of pathological processes.

Aim: This study aimed to evaluate the AnxA1 expression in renal tissues, in order to explore its potential role in LN pathogenesis.

Methods: AnxA1 expression was performed by immunohistochemistry staining in renal biopsies of 24 LN patients compared to 8 controls.

Results: LN patient's biopsies showed an increased distribution of AnxA1 in glomeruli compared to controls (p=0.00019). When comparing AnxA1 expression in different LN classes, a high AnxA1 intensity score was positively correlated with glomerular proliferation.

Conclusion: Our data suggest AnxA1 as a useful marker to differentiate between severe proliferative and non severe proliferative classes of LN.

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狼疮性肾炎中膜联蛋白A1的表达。

简介：狼疮肾炎（Lupus nephroritis， LN）是一种由系统性红斑狼疮引起的免疫复合物肾小球肾炎。它与发病率和死亡率的增加有关。在LN中，免疫反应失调是重要的致病途径之一。膜联蛋白A1 （AnxA1）作为一种抗炎介质，除多种病理过程外，在免疫应答中起关键作用。目的：研究肾组织中AnxA1的表达，探讨其在LN发病中的潜在作用。方法：采用免疫组化染色法检测24例LN患者肾活检组织中AnxA1的表达，对照组8例。结果：LN患者活检显示，与对照组相比，肾小球中AnxA1的分布增加（p=0.00019）。当比较不同LN类别的AnxA1表达时，高AnxA1强度评分与肾小球增殖呈正相关。结论：我们的数据表明，AnxA1是区分严重增生性和非严重增生性LN的有用标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tunisie Medicale Medicine-Medicine (all)

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