Global, regional, and national trends in type 2 diabetes mellitus burden among adolescents and young adults aged 10-24 years from 1990 to 2021: a trend analysis from the Global Burden of Disease Study 2021.
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引用次数: 0
Abstract
Background: Type 2 diabetes mellitus (T2DM) poses an escalating public health challenge among adolescents and young adults worldwide. Despite the rising incidence, comprehensive data on the burden and trends of T2DM in this demographic remain scarce. This study aims to evaluate the burden of T2DM among individuals aged 10-24 years globally, regionally, and nationally from 1990 to 2021.
Methods: Utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, we assessed incidence rates, disability-adjusted life-years (DALYs), and average annual percentage changes (AAPCs) for T2DM in the specified age group. Analyses accounted for variations by age, sex, and socio-demographic index (SDI). Joinpoint regression analysis identified years of significant trend shifts.
Results: The global incidence of T2DM among adolescents and young adults rose from 56.02 per 100,000 (95% UI 43.03-72.32) in 1990 to 123.86 per 100,000 (95% UI 100.43-149.79) in 2021, reflecting an AAPC of 3.01 (95% CI 2.78-3.23). Notable increases were recorded in 1995, 2002, and 2009, with joinpoints indicating significant trend stabilization post-2010 for prevalence and DALYs. The largest relative incidence increase was observed in the 15-19 age group [AAPC 2.97 (95% CI 2.71-3.24)]. Although T2DM mortality was 2.4 times higher in the 15-19 age group compared to the 20-24 age group, the latter exhibited a significantly higher overall mortality rate. Regionally, Oceania recorded the highest incidence rates in 2021, while North Africa and the Middle East showed the greatest AAPCs. High-SDI countries experienced the most substantial increase in T2DM burden, with males comprising 54.8% of cases.
Conclusions: From 1990 to 2021, the global burden of T2DM among adolescents and young adults has markedly increased, underscoring the necessity for targeted, region-specific interventions to address this issue. The observed demographic disparities in mortality rates necessitate the implementation of age-specific strategies. Furthermore, the emergent trends in T2DM indicators warrant urgent attention to mitigate the rising burden in this vulnerable population.
背景：2型糖尿病（T2DM）在全球青少年和年轻人中构成了日益严重的公共卫生挑战。尽管发病率不断上升，但关于该人群中2型糖尿病负担和趋势的综合数据仍然很少。本研究旨在评估1990年至2021年全球、地区和国家10-24岁人群中2型糖尿病的负担。方法：利用全球疾病、损伤和危险因素负担研究（GBD） 2021的数据，我们评估了特定年龄组T2DM的发病率、残疾调整生命年（DALYs）和平均年百分比变化（AAPCs）。分析表明年龄、性别和社会人口指数（SDI）的差异。连接点回归分析确定了显著趋势变化的年份。结果：全球青少年和年轻人T2DM发病率从1990年的56.02 / 10万（95% CI 43.03-72.32）上升到2021年的123.86 / 10万（95% CI 100.43-149.79）， AAPC为3.01 （95% CI 2.78-3.23）。1995年、2002年和2009年记录了显著的增长，其结合点表明患病率和伤残调整生命年在2010年后有显著的稳定趋势。15-19岁年龄组的相对发病率增幅最大[AAPC 2.97 (95% CI 2.71-3.24)]。尽管15-19岁年龄组的T2DM死亡率是20-24岁年龄组的2.4倍，但后者的总死亡率明显更高。从区域来看，大洋洲在2021年的发病率最高，而北非和中东的AAPCs最高。高sdi国家的2型糖尿病负担增加最为显著，男性占54.8%。结论：从1990年到2021年，全球青少年和年轻人的2型糖尿病负担显著增加，强调有必要采取有针对性的、针对特定区域的干预措施来解决这一问题。观察到的死亡率人口差异要求执行针对年龄的战略。此外，2型糖尿病指标的新趋势值得紧急关注，以减轻这一弱势人群日益增加的负担。
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The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics.
We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
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