Characteristics of Cognitive Event-Related Potential Components and N170 Source Analysis in Patients with Acute Cerebellar Infarction.

Abstract

This study aims to evaluate cognitive impairments in patients with acute cerebellar infarction using event-related potentials (ERP) and electrophysiological source imaging (ESI). Thirty patients with acute cerebellar infarction and 32 healthy volunteers were selected. Cognitive potentials were recorded and measured using a visual Oddball paradigm. Source analysis of the N170 component was performed using standardized low-resolution brain electromagnetic tomography (sLORETA) to compare the standardized current density distribution between the two groups under different stimuli. For inverted and upright face stimuli, the amplitudes of N170, VPP, and N300 in the patient group were significantly lower than those in the control group (p < 0.05). For upright house stimuli, the VPP amplitude in the patient group was also lower than that in the control group (p < 0.05). Source analysis revealed that the brain regions with significant differences between the acute cerebellar infarction group and the control group included the temporal and parietal lobes. Specifically, activation in the precuneus was reduced during inverted face stimuli; activation in the middle temporal gyrus was reduced during upright face stimuli; and activation in the middle temporal gyrus and fusiform gyrus was increased during both inverted and upright house stimuli. Patients with acute cerebellar infarction exhibit abnormal P100, N170/VPP, and N300 amplitudes. Source analysis of the N170 component revealed altered activation in the middle and inferior temporal gyri, fusiform gyrus, middle occipital gyrus, and precuneus, which play a role in selective cognitive impairments following cerebellar infarction.