Effects of Pregnancy and Lactation on Bone Microstructure and Material Properties in a Rat Model of Bariatric Surgery.

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Calcified Tissue International Pub Date : 2025-01-04 DOI:10.1007/s00223-024-01321-1
Malory Couchot, Françoise Schmitt, Morgane Mermet, Céline Fassot, Guillaume Mabilleau
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Abstract

Obesity is a major public health issue worldwide. Despite various approaches to weight loss, the most effective technique for reducing obesity, as well as diabetes and associated diseases, is bariatric surgery. Increasingly, young women without children are undergoing bariatric surgery, vertical sleeve gastrectomy (VSG) being the most common procedure nowadays. However, despite several reports suggesting bone loss after VSG, little is known about the potential additive effects of gestation and lactation after VSG to bone health. This study investigated the combined effects of pre-gestational VSG and subsequent gestation/lactation on bone metabolism in a rat model fed a high fat high sugar (HFHS) diet, with a focus on bone biomechanics, mass, microarchitecture and material properties. Furthermore, bone mass and remodelling were followed longitudinally by microCT prior to surgery, 4 weeks post-surgery, after weaning and at sacrifice. Significant alterations in bone mass and microarchitecture, characterized by changes in trabecular thickness and number, as well as changes in bone formation and resorption were influenced by both surgery and reproductive demands. Mechanical testing at sacrifice demonstrated compromised long bone fragility, in rat with HFHS regardless of the surgical procedure (Sham or VSG). Furthermore, analysis of bone material properties highlighted potential disruptions in the pattern of bone mineralization in sham and VSG animals fed a HFHS diet. These findings underscore the complex interplay between pre-gestational VSG and subsequent gestation/lactation in modulating bone metabolism in the investigated rat model. The preclinical rat model may help with optimizing surgical strategies and developing targeted interventions to mitigate potential bone-related complications associated with VSG in reproductive-aged individuals.

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妊娠和哺乳对减肥手术大鼠模型骨结构和材料性能的影响。
肥胖是世界范围内的一个主要公共卫生问题。尽管有各种各样的减肥方法,但减少肥胖、糖尿病和相关疾病最有效的技术是减肥手术。越来越多没有孩子的年轻女性接受减肥手术,竖袖胃切除术(VSG)是目前最常见的手术。然而,尽管有一些报道表明VSG后骨质流失,但对于VSG后妊娠和哺乳对骨骼健康的潜在附加效应知之甚少。本研究以高脂高糖(HFHS)饲粮模型大鼠为研究对象,研究了妊娠前期和妊娠期/哺乳期VSG对其骨代谢的综合影响,重点研究了骨生物力学、质量、微结构和材料性能。此外,术前、术后4周、断奶后和牺牲时,通过显微ct纵向跟踪骨量和重塑。骨量和微结构的显著改变,以骨小梁厚度和数量的变化为特征,以及骨形成和骨吸收的变化受到手术和生殖需求的影响。牺牲时的力学测试表明,HFHS大鼠的长骨脆性受损,无论手术方式如何(假手术或VSG)。此外,对骨材料特性的分析强调了饲喂HFHS饮食的假手术和VSG动物骨矿化模式的潜在破坏。这些发现强调了在所研究的大鼠模型中,妊娠前VSG和随后的妊娠/哺乳期在调节骨代谢方面的复杂相互作用。临床前大鼠模型可能有助于优化手术策略和制定有针对性的干预措施,以减轻育龄个体与VSG相关的潜在骨相关并发症。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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