Are impulsive compulsive behaviors associated with levodopa-induced dyskinesia? A Brazilian cross-sectional study

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Clinical Neurology and Neurosurgery Pub Date : 2025-02-01 DOI:10.1016/j.clineuro.2024.108708

Beatriz A. Anjos G. Veiga , Carolina Candeias da Silva , Roberta Arb Saba , Sonia Maria C.A. Silva , Henrique Ballalai Ferraz , Vanderci Borges

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Abstract

Purpose of this research

To study the association between ICBs and LIDs and to assess the predictors of ICBs in this sample.

Methods

We intentionally evaluated 90 Brazilian PD patients younger than 60 in one evaluation that included the application of Questionnaire for Impulsive Compulsive Disorders - Current Short (QUIP-CS), Barratt Impulsive Scale-11 (BIS-11), Beck Depression Inventory-II (BDI-II), Unified Parkinson's Disease Rating Scale parts III and IV, Unified Dyskinesia Rating Scale (UDysRS), and a cognitive assessment.

Results

ICB group had a longer PD duration (8.8 ± 5.2 y vs. 6.3 ± 3.3 y, p = 0.01), higher LEDDs (852.1 ± 381.8 mg vs.669.8 ± 404.4 mg, p = 0.03), higher BIS-11 scores (64.3 ± 12.7 vs. 58.6 ± 9.7, p = 0.01) and higher historical off-dystonia sub-scores (3.9 ± 5.0 vs. 2.0 ± 4.0, p = 0,05). LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk in both logistic models performed. MCI did not relate to ICBs.

Conclusion

In this study, LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk.

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冲动强迫行为与左旋多巴诱发的运动障碍有关吗？巴西横断面研究。

本研究的目的：研究ICBs与lid之间的关系，并评估该样本中ICBs的预测因素。方法：我们对90名年龄小于60岁的巴西PD患者进行了一次评估，包括使用冲动强迫症问卷-电流短量表（QUIP-CS）、Barratt冲动量表-11 （BIS-11）、Beck抑郁量表- ii （BDI-II）、统一帕金森病评定量表第三部分和第四部分、统一运动障碍评定量表（UDysRS）和认知评估。结果:正月十五组PD持续时间较长(8.8 ±5.2  y和6.3 ±3.3  y, p = 0.01),高LEDDs( 852.1±381.8  mg vs.669.8 ±404.4  mg, p = 0.03),更高的BIS-11分数(64.3 ± 12.7 vs 58.6 ± 9.7,p = 0.01)和更高的历史off-dystonia小分(3.9 ± 5.0 vs 2.0 ± 4.0,p = 0 05)。在两种逻辑模型中，盖子没有增加ICB风险，老年PD发病降低，PD之前的冲动性增加了ICB风险。MCI与ICBs无关。结论：在本研究中，盖子没有增加ICB风险，老年PD发病降低，而PD前的冲动性增加了ICB风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.