Nonhuman primate antigenic cartography of SARS-CoV-2.

IF 6.9 1区生物学 Q1 CELL BIOLOGY Cell reports Pub Date : 2025-01-28 Epub Date: 2025-01-03 DOI:10.1016/j.celrep.2024.115140

Annika Rössler, Antonia Netzl, Ninaad Lasrado, Jayeshbhai Chaudhari, Barbara Mühlemann, Samuel H Wilks, Janine Kimpel, Derek J Smith, Dan H Barouch

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Abstract

Virus neutralization profiles against primary infection sera and corresponding antigenic cartography are integral part of the COVID-19 and influenza vaccine strain selection processes. Human single variant exposure sera have previously defined the antigenic relationships among SARS-CoV-2 variants but are now largely unavailable due to widespread population immunity. Therefore, antigenic characterization of future SARS-CoV-2 variants will require an animal model, analogous to using ferrets for influenza virus. We evaluated neutralization profiles against 23 SARS-CoV-2 variants in nonhuman primates (NHPs) after single variant exposure and generated an NHP-derived antigenic map. We identified a distant antigenic region occupied by BA.2.86, JN.1, and the descendants KP.2, KP.3, and KZ.1.1.1. We also found that the monovalent XBB.1.5 mRNA vaccine induced broad immunity against the mapped antigenic space. In addition, substantial concordance was observed between our NHP-derived and two human antigenic maps, demonstrating the utility of NHPs as a surrogate for antigenic cartography in humans.

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SARS-CoV-2 的非人灵长类抗原图谱。

针对原发性感染血清的病毒中和谱和相应的抗原制图是COVID-19和流感疫苗株选择过程的组成部分。人类单变体暴露血清以前已经确定了SARS-CoV-2变体之间的抗原关系，但由于广泛的人群免疫，现在基本上无法获得。因此，未来SARS-CoV-2变体的抗原表征将需要一种动物模型，类似于用雪貂来检测流感病毒。我们评估了非人类灵长类动物（NHPs）在单一变异暴露后对23种SARS-CoV-2变异的中和谱，并生成了NHPs衍生的抗原图谱。我们发现BA.2.86、JN.1和后代KP.2、KP.3和KZ.1.1.1占据了一个遥远的抗原区。我们还发现，单价XBB.1.5 mRNA疫苗可诱导对已定位抗原空间的广泛免疫。此外，我们的nhp衍生图谱和两幅人类抗原图谱之间也观察到大量的一致性，证明了NHPs作为人类抗原制图的替代品的实用性。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.