Fox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2025-01-03 DOI:10.1002/mdc3.14321

Aaron Lerner, Jennifer R Mammen, Mirinda Tyo, Peggy Auinger, Raunak Al-Rubayie, Yuge Xiao, Connie Marras, Jamie L Adams

{"title":"Fox Insight: Most Bothersome Symptoms in Early-Stage Parkinson's Disease.","authors":"Aaron Lerner, Jennifer R Mammen, Mirinda Tyo, Peggy Auinger, Raunak Al-Rubayie, Yuge Xiao, Connie Marras, Jamie L Adams","doi":"10.1002/mdc3.14321","DOIUrl":null,"url":null,"abstract":"Background: Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).Objectives: To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.Methods: Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.Results: Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tremor (55.9%) and gait issues (36.7%). Top most bothersome non-motor symptoms were pain/discomfort (33.1%) and physical fatigue (27.5%).Conclusions: This study underscores the complexity of early PD symptomatology. Future consideration of diverse patient experiences is needed to improve therapeutic and outcome measurement strategies.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mdc3.14321","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Limited evidence exists regarding the meaningfulness of symptoms experienced in early Parkinson's disease (PD).

Objectives: To identify the most bothersome symptoms experienced by people with early PD, leveraging data from the Parkinson's Disease Patient Report of Problems (PD-PROP) questionnaire within the Fox Insight Study.

Methods: Individuals with a self-reported diagnosis of PD completed the PD-PROP questionnaire, reporting up to five most bothersome symptoms. Symptom types and frequencies were derived through a combination of human expertise and machine learning.

Results: Participants (N = 8536) were 0.9 years since diagnosis, predominantly white (96%), male (53.3%), and with an average age of 64.6 years. Top most bothersome motor symptoms were tremor (55.9%) and gait issues (36.7%). Top most bothersome non-motor symptoms were pain/discomfort (33.1%) and physical fatigue (27.5%).

Conclusions: This study underscores the complexity of early PD symptomatology. Future consideration of diverse patient experiences is needed to improve therapeutic and outcome measurement strategies.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

福克斯洞察：早期帕金森病最令人烦恼的症状。

背景：关于早期帕金森病（PD）症状意义的证据有限。目的：利用Fox Insight研究中的帕金森病患者问题报告（PD- prop）问卷调查数据，确定早期PD患者经历的最麻烦的症状。方法：自我报告PD诊断的个体完成PD- prop问卷，报告多达五种最令人烦恼的症状。症状类型和频率是通过人类专业知识和机器学习相结合得出的。结果：参与者（N = 8536）为确诊0.9年，以白人（96%）为主，男性（53.3%），平均年龄64.6岁。最令人烦恼的运动症状是震颤（55.9%）和步态问题（36.7%）。最令人烦恼的非运动症状是疼痛/不适（33.1%）和身体疲劳（27.5%）。结论：本研究强调了早期PD症状的复杂性。未来需要考虑不同的患者经验，以改善治疗和结果测量策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)