Relation of squamous differentiation in endometrioid carcinoma with MELF pattern to a high ratio of lymph node metastasis

IF 2.9 4区医学 Q2 PATHOLOGY Pathology, research and practice Pub Date : 2025-02-01 DOI:10.1016/j.prp.2024.155804

Shinichiro Tahara , Kazuaki Sato , Kansuke Kido , Eiichi Morii

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Abstract

One of the known histological patterns of endometrioid carcinoma (EC) in uterine corpus cancer is MELF (microcystic, elongated, and fragmented). MELF is associated with lymphovascular invasion and lymph node metastasis. Besides MELF, it is also known that squamous differentiation (SD) often occurs in EC. SD is known to be no significant difference in the frequency of lymph node metastasis in EC. However, there have been no previous reports on the association between MELF and SD. In this research, we investigated the presence of SD in MELF using an antibody to CK5. We examined 28 cases of EC with MELF pattern, in which 15 cases showed SD. Moreover, the relation of lymph node metastasis to SD was examined. Lymph node dissection was performed in 27 out of 28 cases. Among them, 12 cases showed lymph node metastasis. The ratio of lymph node metastasis was significantly higher in EC with SD (64.3 %, 9 in 14 cases) than EC without SD (23.1 %, 3 in 13 cases). In this study, we first showed the association between SD and MELF and that MELF with SD is associated with a high ratio of lymph node metastasis. It is clinically relevant to recognize that MELF with SD is aggressive with a high ratio of lymph node metastasis.

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MELF型子宫内膜样癌鳞状分化与淋巴结转移率高的关系。

子宫内膜样癌（EC）在子宫体癌中已知的组织学模式之一是MELF（微囊、细长和碎片化）。MELF与淋巴血管侵袭和淋巴结转移有关。除了MELF外，我们还知道EC中经常发生鳞状分化（SD）。已知SD对EC的淋巴结转移频率无显著差异。然而，先前没有关于MELF与SD之间关系的报道。在这项研究中，我们使用一种针对CK5的抗体来研究SD在MELF中的存在。我们检查了28例伴有MELF模式的EC，其中15例出现SD。并观察淋巴结转移与SD的关系。28例患者中27例行淋巴结清扫术。其中12例出现淋巴结转移。伴有SD的EC的淋巴结转移率（64.3 %，14例中9例）明显高于无SD的EC（23.1 %，13例中3例）。在这项研究中，我们首次发现了SD与MELF之间的关联，并且MELF合并SD与高淋巴结转移率相关。认识到MELF合并SD具有侵袭性，淋巴结转移率高，具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.