A Guide to Pediatric Antibiotic Allergy Testing: A Report From the US Drug Allergy Registry

IF 6.6 1区医学 Q1 ALLERGY Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2025-05-01 DOI:10.1016/j.jaip.2024.12.036

John J.O. Accarino MD , Timothy G. Chow MD , Allison Ramsey MD , Christine R.F. Rukasin MD , Alexei Gonzalez-Estrada MD , Anne Y. Liu MD , David A. Khan MD , Kimberly G. Blumenthal MD, MSc , US Drug Allergy Registry Study Team

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Abstract

Pediatric antibiotic labels are common, and unnecessary antibiotic avoidance is associated with negative personal and public health outcomes; as a result, there is an increasing emphasis on the importance of pediatric antibiotic allergy evaluations. Different testing strategies have been advised, including skin testing and challenge testing with varied doses and duration. Established consensus testing protocols are lacking. The US Drug Allergy Registry Pediatrics (USDAR-Peds) is a multisite prospective study designed for epidemiology and outcome evaluations of pediatric drug hypersensitivity reactions. Interpretation of multisite data requires a uniform clinical approach, and the USDAR-Peds standardized protocols were developed in response to this need. This rostrum aims to provide a rationale and framework for standardization for pediatric antibiotic allergy protocols and assessment of positive reactions through a pediatric-specific adaptation of the USDAR immediate reaction grading scale to create consistency for multisite research collaboration efforts such as USDAR-Peds.

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儿童抗生素过敏测试指南：来自美国药物过敏登记处的报告。

儿科抗生素标签很常见，不必要的抗生素避免与负面的个人和公共卫生结果相关；因此，越来越多的人强调儿科抗生素过敏评估的重要性。提出了不同的测试策略，包括皮肤测试和不同剂量和持续时间的挑战测试。缺乏已建立的共识测试协议。美国儿科药物过敏登记（USDAR-Peds）是一项多地点前瞻性研究，旨在研究儿童药物超敏反应（HSRs）的流行病学和结果评估。多位点数据的解释需要统一的临床方法，USDAR-Peds的标准化方案就是针对这一需求而制定的。该论坛旨在通过针对儿科的USDAR即时反应分级量表，为儿科抗生素过敏协议的标准化和阳性反应评估提供理论基础和框架，从而为USDAR- peds等多站点研究合作努力创造一致性。

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来源期刊

Journal of Allergy and Clinical Immunology-In Practice ALLERGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

11.10

自引率

9.60%

发文量

683

审稿时长

50 days

期刊介绍： JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases. This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders. The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.