Efficacy of concurrent utilization of estradiol valerate and Chinese herbal capsule in managing premature ovarian failure.

Abstract

The objective of this study was to examine the efficacy of the concurrent utilization of estradiol valerate and kuntai capsule (a Chinese herbal preparation) in addressing premature ovarian failure (POF) and its ramifications for ovarian hemodynamics and sex hormone levels. A retrospective study of 104 patients with POF was conducted, dividing them into control (n=50) and observation groups (n=54). The control group received estradiol valerate, while the observation group received estradiol valerate and KunTai capsules over 12 weeks. Clinical effectiveness, ovarian pulsatility index (PI), resistance index (RI), hormone levels, ovarian function, and adverse reactions were analyzed. The observation group showed significantly improved PI, RI, LH, FSH, E2 levels, and ovarian function in relative to the control group (P<0.05). We conclude that the concurrent use of estradiol valerate and KunTai capsules improves ovarian hemodynamics and hormone levels, offering significant clinical benefits.