Approaches to regenerative endodontic therapy in necrotic human teeth with complete root formation: a systematic review.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Clinical Oral Investigations Pub Date : 2025-01-06 DOI:10.1007/s00784-024-06137-9

Rafaela Hartmann Kasper, Kathleen Sobieray Schneider, Myrian Camara Brew, José Antonio Poli Figueiredo, Fernando Branco Barletta

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Abstract

Introduction: Regenerative endodontic procedures (REPs) aim to replace damaged dental structures and regenerate the dentin-pulp complex. Initially focused on teeth with incomplete root formation, recent research shows promise for necrotic teeth with complete root formation.

Methodology: This review, following PRISMA guidelines and registered in PROSPERO, included clinical studies on regenerative endodontic therapy in necrotic human teeth with complete root formation. Searches in PubMed, Web of Science, Embase, and Cochrane Library identified 10 studies meeting the criteria.

Results: The studies showed variable regenerative endodontic protocols and materials, with success rates ranging from 60 to 100%. Most studies reported favorable outcomes, such as symptom resolution and bone healing.

Discussion: Regenerative endodontic therapy for necrotic teeth with complete root formation shows high success rates, but the variability in protocols calls for standardized guidelines and further high-quality trials.

Conclusion: Regenerative endodontic therapy is a promising alternative to conventional treatments for necrotic teeth with complete root formation, with demonstrated potential for restoring pulp vitality.Future research should optimize protocols and materials for consistent success.

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再生根管治疗具有完全根形成的坏死牙齿的方法：系统回顾。

再生牙髓治疗（REPs）的目的是替换受损的牙齿结构和再生牙本质-牙髓复合体。最初的研究重点是牙根形成不完全的牙齿，最近的研究显示了对牙根形成完全的坏死牙齿的治疗前景。方法：这篇综述，遵循PRISMA指南并在PROSPERO上注册，包括再生牙髓治疗具有完全根形成的坏死牙齿的临床研究。在PubMed、Web of Science、Embase和Cochrane Library中搜索，确定了10项符合标准的研究。结果：研究显示再生牙髓治疗方案和材料各不相同，成功率从60%到100%不等。大多数研究报告了良好的结果，如症状缓解和骨愈合。讨论：再生牙髓治疗具有完全根形成的坏死牙齿显示出很高的成功率，但方案的可变性需要标准化的指导方针和进一步的高质量试验。结论：再生牙髓治疗是一种很有前途的替代传统治疗方法，可以恢复牙髓活力。未来的研究应优化方案和材料，以取得一致的成功。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.