RETRACTION: Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway

Abstract

RETRACTION: S. Ghanaatgar-Kasbi, F. Amerizadeh, F. Rahmani, S. M. Hassanian, M. Khazaei, G. A. Ferns and A. Avan, “Amp-Kinase Inhibitor Dorsomorphin Reduces the Proliferation and Migration Behavior of Colorectal Cancer Cells by Targeting the Akt/mTOR Pathway,” IUBMB Life 71, no. 12 (2019): 1929–1936, https://doi.org/10.1002/iub.2136.

The above article, published online on 30 July 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Efstathios S. Gonos; International Union of Biochemistry and Molecular Biology; and Wiley Periodicals LLC. The retraction has been agreed following an investigation into concerns raised by a third party which revealed that the TBHP image and the Dorso 5μM image in Figure 3b contained an overlap with images published elsewhere by some of the same authors. In both instances of duplication, the images were used to represent different experimental conditions. Furthermore, the western blot in Figure 4D has been inappropriately edited and there is evidence that the bands have been spliced without clearly marking the splice sites. The authors provided an explanation and some data but this was not considered sufficient to address the concerns. As a result, the editors have lost confidence in the data presented and consider the conclusions substantially compromised. The authors disagree with the retraction.