Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly.

IF 1.7 4区医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2025-02-05 Epub Date: 2025-01-06 DOI:10.1097/WNR.0000000000002128

Huarong Yang, Qinhua Wu, Jianghuan Zheng

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Abstract

We aimed to unveil the clinical significance of serum 25-hydroxyvitamin D (25-OH-VD), insulin-like growth factor 1 (IGF-1), and beta-2 microglobulin (β2-MG) levels in cognitive dysfunction after ischemic stroke (IS) in the elderly. A total of 160 geriatric IS patients admitted to our hospital were retrospectively collected. The patients' serum 25-OH-VD, IGF-1, and β2-MG levels were detected, and the correlation between the three levels and the patients' National Institutes of Health Stroke Scale (NIHSS) and Montreal Cognitive Assessment (MoCA) scores was tested by the Pearson test. The diagnostic values of 25-OH-VD, IGF-1, and β2-MG for cognitive dysfunction and risk factors inducing cognitive dysfunction in the elderly after IS were evaluated. NIHSS score was negatively correlated with serum 25-OH-VD and IGF-1 levels, and positively correlated with serum β2-MG levels; MoCA score exhibited an inverse correlation. Diabetes, years of education <12 years, age, and serum high-sensitive C-reactive protein, cystatin C, 25-OH-VD, IGF-1, and β2-MG levels were independent factors for the development of cognitive dysfunction after IS in the elderly. The detection of 25-OH-VD, IGF-1, and β2-MG may be important for assessing the occurrence of cognitive dysfunction and the severity of the disease in patients.

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25-羟基维生素D、胰岛素样生长因子1、β -2微球蛋白在老年人缺血性脑卒中后认知功能障碍中的表达及临床意义

我们旨在揭示血清25-羟基维生素D （25-OH-VD）、胰岛素样生长因子1 （IGF-1）和β -2微球蛋白（β2-MG）水平在老年人缺血性卒中（IS）后认知功能障碍中的临床意义。回顾性收集我院收治的160例老年IS患者。检测患者血清25-OH-VD、IGF-1、β2-MG水平，并采用Pearson检验检验这3项水平与患者美国国立卫生研究院卒中量表（NIHSS）和蒙特利尔认知评估（MoCA）评分的相关性。评价25-OH-VD、IGF-1、β2-MG对老年IS后认知功能障碍及诱发认知功能障碍危险因素的诊断价值。NIHSS评分与血清25-OH-VD、IGF-1水平呈负相关，与血清β2-MG水平呈正相关；MoCA评分呈负相关。糖尿病，多年的教育

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.