{"title":"The effect of consecutive ejaculation on the sperm parameters in the oligo-astheno-teratozoospermia (OAT) men.","authors":"Akram Hosseini, Zahra Borzouie, Parvin Khalili, Mahboubeh Vatanparast","doi":"10.1017/S0967199424000443","DOIUrl":null,"url":null,"abstract":"<p><p>Recently, the World Health Organization recommendation for abstinence time for semen analysis has been challenged in some studies and many of them have supported the advantages of a second short abstinence ejaculation. More evidence is needed to approve this for clinical use. This study aimed to compare the average routine abstinence time (2-7 days) with the short time (1-2 h) on sperm quality based on functional parameters in a population of oligo-astheno-teratozoospermia (OAT) men. The semen samples were retrieved from 50 men with OAT two times: one standard 2-7 days (long ejaculation) and short duration trimming (1-2 hours later the first ejaculation). All semen parameters as well as sperm DNA integrity were compared between groups. Results showed that mean sperm concentration (10.40 vs. 8.76), total sperm count (28.53 vs. 12.24) and mean semen volume (2.69 vs. 1.40) were higher in the first ejaculation (2-7 days of abstinence), while progressive motility (20.52 vs. 13.32), non-progressive motility (53.46 vs. 48.86), morphology (2.46 vs. 1.46) and viability (83.90 vs. 77.96) were significantly higher in the second ejaculation (<i>P</i> < 0.05). The second sample also showed lower immotile (26.82 vs. 38.02) and DNA fragmentation (19.5 vs. 26.96) (<i>P</i> < 0.05). Taking all data into account, an additional short abstinence period (AP) may be a simple and helpful strategy to obtain better sperm quality in couples with male infertility causes, especially in OAT patients. The recommended current guidelines regarding the AP may need to be revisited in severe male factors.</p>","PeriodicalId":24075,"journal":{"name":"Zygote","volume":" ","pages":"1-7"},"PeriodicalIF":1.5000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zygote","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1017/S0967199424000443","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Recently, the World Health Organization recommendation for abstinence time for semen analysis has been challenged in some studies and many of them have supported the advantages of a second short abstinence ejaculation. More evidence is needed to approve this for clinical use. This study aimed to compare the average routine abstinence time (2-7 days) with the short time (1-2 h) on sperm quality based on functional parameters in a population of oligo-astheno-teratozoospermia (OAT) men. The semen samples were retrieved from 50 men with OAT two times: one standard 2-7 days (long ejaculation) and short duration trimming (1-2 hours later the first ejaculation). All semen parameters as well as sperm DNA integrity were compared between groups. Results showed that mean sperm concentration (10.40 vs. 8.76), total sperm count (28.53 vs. 12.24) and mean semen volume (2.69 vs. 1.40) were higher in the first ejaculation (2-7 days of abstinence), while progressive motility (20.52 vs. 13.32), non-progressive motility (53.46 vs. 48.86), morphology (2.46 vs. 1.46) and viability (83.90 vs. 77.96) were significantly higher in the second ejaculation (P < 0.05). The second sample also showed lower immotile (26.82 vs. 38.02) and DNA fragmentation (19.5 vs. 26.96) (P < 0.05). Taking all data into account, an additional short abstinence period (AP) may be a simple and helpful strategy to obtain better sperm quality in couples with male infertility causes, especially in OAT patients. The recommended current guidelines regarding the AP may need to be revisited in severe male factors.
最近，世界卫生组织关于精液分析的禁欲时间的建议在一些研究中受到了挑战，其中许多研究都支持第二次短时间禁欲射精的优势。需要更多的证据来批准临床使用。本研究旨在比较低弱畸形精子症（OAT）男性的平均常规禁欲时间（2-7天）和短时间（1-2小时）对精子质量的影响。从50名患有OAT的男性中抽取两次精液样本：一次是标准的2-7天（长射精），另一次是短时间的修剪（第一次射精后1-2小时）。比较各组小鼠精液各项参数及精子DNA完整性。结果显示，第一次射精（禁欲2 ~ 7 d）时平均精子浓度（10.40 vs. 8.76）、总精子数（28.53 vs. 12.24）和平均精液量（2.69 vs. 1.40）较高，第二次射精时进行性活力（20.52 vs. 13.32）、非进行性活力（53.46 vs. 48.86）、形态（2.46 vs. 1.46）和活力（83.90 vs. 77.96）显著高于第一次射精（P < 0.05）。第二个样本的不动性（26.82比38.02）和DNA断裂性（19.5比26.96）也较低（P < 0.05）。考虑到所有的数据，一个额外的短禁欲期（AP）可能是一个简单而有用的策略，以获得更好的精子质量对男性不育的夫妇，特别是在OAT患者。对于严重的男性因素，目前关于AP的建议指南可能需要重新审视。
期刊介绍：
An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies on gametogenesis through fertilization to gastrulation in animals and humans. The scope has been expanded to include clinical papers, molecular and developmental genetics. The editors will favour work describing fundamental processes in the cellular and molecular mechanisms of animal development, and, in particular, the identification of unifying principles in biology. Nonetheless, new technologies, review articles, debates and letters will become a prominent feature.
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