Photoinduced Pd-Catalyzed 1,4-Dicarbofunctionalization of 1,3-Butadienes via Aliphatic C–H Bond Elaboration

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-01-07 DOI:10.1021/acs.orglett.4c04410

Dan-Xing Wu, Xiao-Yun Ruan, Wen-Qian Zhang, Mostafa Sayed, Zhi-Yong Han

引用次数: 0

Abstract

A three-component coupling strategy for 1,4-dicarbofunctionalization of 1,3-butadiene with C–H bearing substrates has been developed using photoinduced Pd catalysis, with aryl bromide serving as the hydrogen atom transfer (HAT) reagent. This photocatalytic coupling process achieves functionalized oxindole motifs in good yield and regioselectivity under mild reaction conditions. The versatility and synthetic utility of this method are demonstrated through the addition of a variety of C–H-bearing partners and various oxindole substrates to both substituted and unsubstituted butadiene.

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光诱导pd催化1,3-丁二烯通过脂肪族C-H键精化的1,4-二碳功能化

以芳基溴为氢原子转移（HAT）试剂，利用光诱导Pd催化，建立了1,4-二碳功能化1,3-丁二烯与含碳- h底物的三组分偶联策略。该光催化偶联工艺在温和的反应条件下以良好的收率和区域选择性获得了功能化的氧化吲哚基序。通过在取代丁二烯和未取代丁二烯上添加各种含碳氢化合物和各种氧吲哚底物，证明了该方法的通用性和合成实用性。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.

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