Cullen R. Schull, Jing Cao, Sophia R. Mitton-Fry, Mara Mrksich, Karl A. Scheidt
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引用次数: 0
Abstract
C(sp3)–H bond functionalization is a powerful strategy for the synthesis of organic compounds due their abundance in simple starting materials. Photoredox catalysis has led to a diverse array of enabling C(sp3)–H activation strategies; however, a general platform for the direct functionalization of C(sp3)–H to carboxylic acid derivatives remains elusive. Disclosed herein is the development of a cooperative NHC/photoredox-catalyzed C(sp3)–H esterification transformation. This method enables access to benzylic, α-heteroatom, and formal β-esterification products in moderate to high yields under mild reaction conditions.
期刊介绍：
ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels.
The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.
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