{"title":"Inside Cover: Tandem-Controlled Dynamic DNA Assembly Enables Temporally-Selective Orthogonal Regulation of cGAS–STING Stimulation (Angew. Chem. Int. Ed. 7/2025)","authors":"Xiangfei Li, Dr. Fangzhi Yu, Prof. Lele Li","doi":"10.1002/anie.202424929","DOIUrl":null,"url":null,"abstract":"<p>Spatiotemporally controlled orthogonal regulation of cGAS–STING stimulation has been achieved in the Research Article (e202417916) by Xiangfei Li, Fangzhi Yu and Lele Li. In the approach, enzyme-triggered DNA assembly allows the cGAS–STING stimulation, while light-induced fragmentation of the double-stranded DNA enables termination of such stimulation, thereby achieving orthogonal control over the immune regulation.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"64 7","pages":""},"PeriodicalIF":16.9000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.202424929","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie International Edition","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/anie.202424929","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Spatiotemporally controlled orthogonal regulation of cGAS–STING stimulation has been achieved in the Research Article (e202417916) by Xiangfei Li, Fangzhi Yu and Lele Li. In the approach, enzyme-triggered DNA assembly allows the cGAS–STING stimulation, while light-induced fragmentation of the double-stranded DNA enables termination of such stimulation, thereby achieving orthogonal control over the immune regulation.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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