Ainara Jauregi-Zinkunegi, Carey E. Gleason, Barbara Bendlin, Ozioma Okonkwo, Bruce P. Hermann, Kaj Blennow, Henrik Zetterberg, Eef Hogervorst, Sterling C. Johnson, Rebecca Langhough, Kimberly D. Mueller, Davide Bruno
{"title":"Menopausal hormone therapy is associated with worse levels of Alzheimer's disease biomarkers in APOE ε4-carrying women: An observational study","authors":"Ainara Jauregi-Zinkunegi, Carey E. Gleason, Barbara Bendlin, Ozioma Okonkwo, Bruce P. Hermann, Kaj Blennow, Henrik Zetterberg, Eef Hogervorst, Sterling C. Johnson, Rebecca Langhough, Kimberly D. Mueller, Davide Bruno","doi":"10.1002/alz.14456","DOIUrl":null,"url":null,"abstract":"Menopausal hormone therapy (MHT), along with the apolipoprotein E (<i>APOE</i>) ε4 allele, has been suggested as a possible risk factor for Alzheimer's disease (AD). However, the relationship between MHT and cerebrospinal fluid (CSF) biomarkers is unknown: we investigated this association, and whether <i>APOE</i> ε4 carrier status moderates it.","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"12 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/alz.14456","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Menopausal hormone therapy (MHT), along with the apolipoprotein E (APOE) ε4 allele, has been suggested as a possible risk factor for Alzheimer's disease (AD). However, the relationship between MHT and cerebrospinal fluid (CSF) biomarkers is unknown: we investigated this association, and whether APOE ε4 carrier status moderates it.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
