Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin MRI Study

IF 4.8 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2025-01-08 DOI:10.1111/cns.70214

Yuelin Fang, Cheng Zhou, Bingting Zhu, Jiasi Liu, Sicheng Liu, Xiaojun Guan, Tao Guo, Xiaojun Xu, Minming Zhang, Jun Tian, Xinzhen Yin, Baorong Zhang, Guohua Zhao, Yaping Yan

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Abstract

Objective

Our aim was to research the neuromelanin-sensitive magnetic resonance imaging (NM-MRI) features of the locus coeruleus (LC) in essential tremor (ET) patients of various cognitive states and to explore the relationships between these features and cognition.

Methods

We recruited three groups of participants, including 30 ET patients with mild cognitive impairment (ET-MCI), 57 ET patients with normal cognition (ET-NC), and 105 healthy controls (HCs). All participants underwent MRI scanning and clinical evaluation. Through NM-MRI images, we compared the contrast-to-noise ratio of LC (CNR_LC) between groups and evaluated the relationships between CNR_LC and cognitive scales.

Results

Compared to HCs, ET-MCI patients had a substantially lower CNR_LC value (p = 0.017). The CNR_LC of ET-NC patients was intermediate between that of ET-MCI patients and HCs. Furthermore, a partial correlation analysis in ET-MCI patients, controlling for age, gender, and education level, showed that higher CNR_LC values correlate with better performance on the Montreal cognitive assessment test and the trail making test A.

Conclusion

LC degeneration in ET patients may partially contribute to cognitive decline, suggesting that the LC norepinephrine system deserves further research on the mechanism of cognitive decline of ET patients as well as the development of targeted drugs.

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原发性震颤伴轻度认知障碍的蓝斑变性：神经黑色素MRI研究。

目的：研究特发性震颤（ET）患者不同认知状态下蓝斑区（LC）的神经黑色素敏感磁共振成像（NM-MRI）特征，并探讨这些特征与认知的关系。方法：我们招募了三组参与者，包括30例轻度认知障碍ET患者（ET- mci）， 57例认知正常ET患者（ET- nc）和105例健康对照（hc）。所有参与者都进行了MRI扫描和临床评估。通过纳米核磁共振成像（NM-MRI）图像，比较各组间LC （CNRLC）的对比噪声比，并评估CNRLC与认知量表的关系。结果：与hcc患者相比，ET-MCI患者的CNRLC值显著降低（p = 0.017）。ET-NC患者的CNRLC介于ET-MCI患者和hc患者之间。此外，对ET-MCI患者进行偏相关分析，在控制年龄、性别和受教育程度的情况下，发现CNRLC值越高，在蒙特利尔认知评估测试和造径测试a中的表现越好。ET患者LC退行性变可能是认知能力下降的部分原因，提示LC去甲肾上腺素系统值得进一步研究ET患者认知能力下降的机制并开发靶向药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.