Covalent Organic Framework Nanofilm-Assisted Laser Desorption Ionization Mass Spectrometry for Rapid Screening of Parabens in Personal Care Products

IF 1.7 3区化学 Q4 BIOCHEMICAL RESEARCH METHODS Rapid Communications in Mass Spectrometry Pub Date : 2025-01-09 DOI:10.1002/rcm.9987

Wenjun Zheng, Jingjing Yan, Yingxue Jin, Zian Lin, Zongwei Cai

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Abstract

Rational

People are widely exposed to parabens in their daily life, but parabens are endocrine disrupting chemicals that pose a threat to human health. Therefore, establishing a rapid screening method to enhance monitoring of parabens is necessary. Herein, a covalent organic framework (COF) nanofilm-assisted laser desorption ionization mass spectrometry (LDI-MS) method was established to screen parabens in personal care products (PCPs).

Methods

TAPB-TFPB-COF nanofilm was synthesized on indium tin oxide (ITO) glass and used as LDI-MS substrates. To observe the practicability of TAPB-TFPB-COF nanofilm-assisted LDI-MS, the results of this method for analyzing small molecules such as parabens, estrogens, and bisphenols were compared with those of the conventional organic matrix 9-aminoacridine (9-AA), and the reproducibility and detection limit were further verified. Finally, the method was applied to screen parabens in PCPs.

Results

TAPB-TFPB-COF nanofilm-assisted LDI-MS analyzed small molecules such as parabens, estrogens, and bisphenols with higher mass spectral signals and cleaner mass spectral backgrounds compared with 9-AA. Meanwhile, the method analyzed methylparaben (MeP) with high reproducibility (RSD = 6.96%) and low detection limit (1.64 μM) and performed well for rapid screening of parabens in PCPs.

Conclusion

TAPB-TFPB-COF nanofilm-assisted LDI-MS for analyzing small molecules such as parabens, estrogens, and amino acids offered the advantages of rapid analysis, a clean background, and good reproducibility. The method was successfully applied to detecting parabens in PCPs, demonstrating the practical utility of LDI-MS based on TAPB-TFPB-COF nanofilm for analyzing parabens in complex samples.

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共价有机框架纳米膜辅助激光解吸电离质谱法快速筛选个人护理产品中对羟基苯甲酸酯类。

理性：人们在日常生活中广泛接触到对羟基苯甲酸酯，但对羟基苯甲酸酯是对人体健康构成威胁的内分泌干扰化学物质。因此，建立一种快速筛选方法来加强对羟基苯甲酸酯的监测是必要的。本文建立了一种共价有机框架（COF）纳米膜辅助激光解吸电离质谱（LDI-MS）筛选个人护理产品（pcp）中对羟基苯甲酸酯类化合物的方法。方法：在氧化铟锡（ITO）玻璃上合成ttap - tfpb - cof纳米膜，作为LDI-MS衬底。为观察TAPB-TFPB-COF纳米膜辅助LDI-MS的实用性，将该方法用于对羟基苯甲酸酯类、雌激素类、双酚类等小分子分析的结果与传统有机基质9-氨基吖啶（9-AA）的结果进行比较，进一步验证其重复性和检出限。最后将该方法应用于pcp中对羟基苯甲酸酯类药物的筛选。结果：与9-AA相比，ttap - tfpb - cof纳米膜辅助LDI-MS分析对羟基苯甲酸酯、雌激素和双酚类小分子，质谱信号更高，质谱背景更清晰。同时，该方法重现性高（RSD = 6.96%），检出限低（1.64 μM），可用于pcp中对羟基苯甲酸甲酯的快速筛选。结论：TAPB-TFPB-COF纳米膜辅助LDI-MS分析对羟基苯甲酸酯类、雌激素、氨基酸等小分子化合物具有分析速度快、背景干净、重现性好等优点。该方法成功应用于pcp中对羟基苯甲酸酯类化合物的检测，验证了基于ttapb - tfpb - cof纳米膜的LDI-MS在复杂样品中对羟基苯甲酸酯类化合物分析中的实用性。

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来源期刊

Rapid Communications in Mass Spectrometry 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

219

审稿时长

2.6 months

期刊介绍： Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.