Association between maternal anemia during pregnancy and risk of eczema in early childhood: A cohort study in Japan.

IF 2.1 4区医学 Q3 ALLERGY Allergologia et immunopathologia Pub Date : 2025-01-01 DOI:10.15586/aei.v53i1.1194

Noboru Yamashita, Keiko Tanaka, Yoshihiro Miyake

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Abstract

Background: There is limited evidence on the association between maternal anemia during pregnancy and the risk of childhood allergic disorders, with regards to atopic eczema. The current pre-birth cohort study aimed to examine the association between maternal anemia during pregnancy and the risk of atopic eczema in Japanese 2-year-olds.

Methods: The study included 1354 Japanese mother-child pairs. Maternal anemia during pregnancy was determined based on self-reported iron treatment for anemia during pregnancy. Eczema was defined according to the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC). Physician-diagnosed atopic eczema was evaluated through a questionnaire completed by the mothers.

Results: The prevalence of maternal anemia during pregnancy was 52.8%. The study found that maternal anemia during pregnancy was associated with an increased risk of physician-diagnosed atopic eczema in children; with an adjusted odds ratio of 1.79 and a 95% confidence interval of 1.04-3.17. However, there was no observed association between maternal anemia during pregnancy and the risk of eczema as defined by the ISAAC criteria.

Conclusions: Although the study relied on self-reported information, it suggested a potential positive association between maternal anemia during pregnancy and the risk of atopic eczema in children.

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妊娠期孕妇贫血与儿童早期湿疹风险之间的关系：日本的一项队列研究

背景：关于怀孕期间孕妇贫血与儿童过敏性疾病风险之间的关联，关于特应性湿疹的证据有限。当前的产前队列研究旨在研究日本2岁儿童妊娠期间母亲贫血与特应性湿疹风险之间的关系。方法：对1354对日本母子进行研究。孕妇在怀孕期间的贫血是根据自我报告的铁治疗来确定的。湿疹是根据国际儿童哮喘和过敏研究（ISAAC）的标准定义的。医生诊断的特应性湿疹通过母亲填写的问卷进行评估。结果：孕产妇妊娠期贫血患病率为52.8%。研究发现，怀孕期间母亲贫血与儿童患医生诊断的特应性湿疹的风险增加有关；调整后的优势比为1.79,95%可信区间为1.04 ~ 3.17。然而，没有观察到怀孕期间孕妇贫血与ISAAC标准定义的湿疹风险之间的关联。结论：尽管该研究依赖于自我报告的信息，但它表明孕期孕妇贫血与儿童特应性湿疹风险之间存在潜在的正相关。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.