Impact of the Inflammatory Burden Index on Prognosis After Hepatectomy for Colorectal Liver Metastasis.

IF 1 4区医学 Q3 SURGERY American Surgeon Pub Date : 2025-01-09 DOI:10.1177/00031348251313993

Hironari Kawai, Kenei Furukawa, Masashi Tsunematsu, Yoshihiro Shirai, Shinji Onda, Koichiro Haruki, Michinori Matsumoto, Norimitsu Okui, Tomohiko Taniai, Toru Ikegami

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Abstract

Background/aim: The aim of this study was to investigate the prognostic impact of the inflammatory burden index (IBI), a novel inflammation-based biomarker, in patients with colorectal liver metastases (CRLM) after hepatic resection.

Patients and methods: One hundred fifty patients with CRLM who underwent hepatectomy were retrospectively analyzed. The IBI was defined as C-reactive protein × neutrophil count/lymphocyte count. The relationship of the IBI with overall survival was investigated by univariate and multivariate analyses.

Results: Seventy-three (49%) patients had a high IBI (>3.45). In univariate analysis, overall survival was significantly worse in patients with lymph node metastases (P = 0.048), high NLR (P = 0.03), and high IBI (P < 0.01). In multivariate analysis, high IBI (P = 0.048) was an independent and significant predictor of overall survival. Patients with a high IBI had more postoperative complications compared with those with a low IBI (P < 0.01).

Conclusion: The IBI was a strong predictor for both short- and long-term outcomes in patients who underwent hepatic resection for CRLM.

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炎症负担指数对结直肠癌肝转移肝切除术后预后的影响。

背景/目的：本研究的目的是研究炎症负担指数（IBI），一种新的基于炎症的生物标志物，在肝切除术后结肠直肠癌肝转移（CRLM）患者中的预后影响。患者和方法：对150例行肝切除术的CRLM患者进行回顾性分析。IBI定义为c反应蛋白×中性粒细胞计数/淋巴细胞计数。通过单因素和多因素分析研究IBI与总生存率的关系。结果：73例（49%）患者IBI高（bbb3.45）。在单因素分析中，淋巴结转移患者（P = 0.048）、高NLR （P = 0.03）和高IBI （P < 0.01）患者的总生存率明显较差。在多变量分析中，高IBI （P = 0.048）是总生存的独立且显著的预测因子。高IBI患者术后并发症发生率高于低IBI患者（P < 0.01）。结论：对于接受肝切除术的CRLM患者，IBI是短期和长期预后的一个强有力的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Surgeon 医学-外科

CiteScore

1.40

自引率

0.00%

发文量

623

期刊介绍： The American Surgeon is a monthly peer-reviewed publication published by the Southeastern Surgical Congress. Its area of concentration is clinical general surgery, as defined by the content areas of the American Board of Surgery: alimentary tract (including bariatric surgery), abdomen and its contents, breast, skin and soft tissue, endocrine system, solid organ transplantation, pediatric surgery, surgical critical care, surgical oncology (including head and neck surgery), trauma and emergency surgery, and vascular surgery.