Heavy Metals Alter the Anti-cancer Potency of Medicinal Plants.

IF 3 4区 医学 Q3 CHEMISTRY, MEDICINAL Anti-cancer agents in medicinal chemistry Pub Date : 2025-01-01 DOI:10.2174/0118715206341220241120132600
Amber Rizwan, Aatiquah Aqeel, Aisha Idris, Humaira Farooqi
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Abstract

This review investigates the outcome of heavy metal contamination on the anti-cancer properties of medicinal plants. Heavy metal pollution is a significant environmental concern globally, often found in soil and water due to industrial activities. Therapeutic plants are recognized because of their therapeutic attributes and their ability to absorbing these contaminants. This study examines how heavy metal exposure modifies the chemical composition and efficacy of medicinal plants against cancer cells. Through a comprehensive review of existing literature and experimental analysis, we explore the mechanisms by which heavy metals interact with bioactive compounds in medicinal plants, affecting their anti-cancer potency. Findings reveal intricate interactions among heavy metals and phytochemicals, leading to variations in cytotoxicity against cancer cells. Comprehending these interactions is crucial for optimizing the utilization of medicinal plants in cancer treatment and for developing approaches to alleviate the impacts of heavy metal contamination on their therapeutic potential. The urgency of this issue cannot be overstated, as it directly impacts our ability to effectively treat cancer and preserve our environment.

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重金属改变药用植物的抗癌功效。
本文综述了重金属污染对药用植物抗癌特性的影响。重金属污染是一个全球性的重大环境问题,通常由于工业活动而存在于土壤和水中。治疗植物因其治疗特性和吸收这些污染物的能力而得到认可。本研究探讨重金属暴露如何改变药用植物抗癌细胞的化学成分和功效。本文通过文献综述和实验分析,探讨了重金属与药用植物中生物活性物质相互作用,影响其抗癌作用的机制。研究结果揭示了重金属和植物化学物质之间复杂的相互作用,导致对癌细胞的细胞毒性变化。了解这些相互作用对于优化药用植物在癌症治疗中的利用以及开发减轻重金属污染对其治疗潜力的影响的方法至关重要。这个问题的紧迫性怎么强调都不为过,因为它直接影响到我们有效治疗癌症和保护环境的能力。
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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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