Extracorporeal membrane oxygenation for catecholaminergic polymorphic ventricular tachycardia: a case report and literature review.

IF 2 3区医学 Q2 PEDIATRICS BMC Pediatrics Pub Date : 2025-01-07 DOI:10.1186/s12887-024-05357-y

Yuna Li, Yao Wu, Yumei Li, Zhen Zhang

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Abstract

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited ion channelopathy characterized by a structurally normal heart sensitive to catecholamines. It primarily presents as Bidirectional ventricular tachycardia (BiVT) and is a significant cause of sudden cardiac death in children.

Case presentation: We report our experience with central Extracorporeal Membrane Oxygenation (ECMO) therapy in a 4-year-old boy with CPVT. Despite these measures, his CPVT was refractory to standard medical treatment and mechanical ventilatory support, with symptom progression. Consequently, ECMO support was initiated in addition to existing treatment. The patient was successfully weaned off ECMO on the 10th day of therapy and was discharged in a good condition. Follow-up after discharge showed favorable outcomes.

Conclusions: The successful outcome in this case was attributed to the application of ECMO, which helped maintain the patient's circulatory status and address progressively worsening cardiogenic shock and uncontrolled ventricular arrhythmia. In such situations, the early use of ECMO can provide essential circulatory support and stability for patients, as demonstrated in this case.

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体外膜氧合治疗儿茶酚胺能型室性心动过速1例并文献复习。

背景：儿茶酚胺能多形性室性心动过速（CPVT）是一种遗传性离子通道病，其特征是心脏结构正常，对儿茶酚胺敏感。它主要表现为双向室性心动过速（BiVT），是儿童心源性猝死的重要原因。病例介绍：我们报告我们的经验中心体外膜氧合（ECMO）治疗一个4岁男孩CPVT。尽管采取了这些措施，但他的CPVT对标准药物治疗和机械通气支持难以治愈，并伴有症状进展。因此，除了现有的治疗外，还开始了ECMO支持。患者于治疗第10天成功停用ECMO，出院时情况良好。出院后随访结果良好。结论：该病例的成功结果归功于ECMO的应用，它有助于维持患者的循环状态，并解决逐渐恶化的心源性休克和不受控制的室性心律失常。在这种情况下，早期使用ECMO可以为患者提供必要的循环支持和稳定性，正如本病例所示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.