Global, regional, and national burden of anxiety disorders during the perimenopause (1990-2021) and projections to 2035.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY BMC Women's Health Pub Date : 2025-01-07 DOI:10.1186/s12905-025-03547-z

Ying Zhang, Ting-Ting Hu, Yong-Ran Cheng, Zhi-Fen Zhang, Jun Su

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Abstract

Purpose: Perimenopause is associated with an increased risk of anxiety disorders, largely due to hormonal changes affecting the body's regulatory feedback mechanisms. This study aims to provide a comprehensive analysis of the global burden of anxiety disorders among perimenopausal women.

Methods: Data from the 2021 Global Burden of Disease (GBD) database were utilized to assess disability-adjusted life years associated with anxiety disorders linked to perimenopause. We calculated trends using the estimated average percent change, and future projections were made using the Bayesian age-period-cohort model to estimate disability-adjusted life year trends for anxiety disorders from 2022 to 2035.

Results: Between 1990 and 2021, the global age-standardized disability-adjusted life year rate for anxiety disorders among perimenopausal women increased from 625.51 (95% uncertainty interval: 429.1-891.09) to 677.15 (95% uncertainty interval: 469.45-952.72), indicating a rising trend with an estimated average percent change of 0.081 (95% confidence interval: 0.0043-0.143). Regional differences were noted, with anxiety disorder burdens varying across areas with different sociodemographic index levels. Projections suggest that by 2035, the global burden of anxiety disorders in perimenopausal women will rise to 1,180.43 per 100,000, a 40.67% increase compared with 2021 levels.

Conclusion: The burden of anxiety disorders during perimenopause is a growing global concern, with a significant increase anticipated in the coming years. Targeted prevention and intervention strategies are urgently needed to mitigate this rising burden and improve mental health outcomes during perimenopause.

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围绝经期焦虑症的全球、区域和国家负担（1990-2021年）以及到2035年的预测。

目的：围绝经期与焦虑障碍的风险增加有关，主要是由于激素的变化影响了身体的调节反馈机制。本研究旨在对全球围绝经期妇女焦虑症负担进行全面分析。方法：使用2021年全球疾病负担（GBD）数据库的数据来评估与围绝经期焦虑症相关的残疾调整生命年。我们使用估计的平均百分比变化来计算趋势，并使用贝叶斯年龄-时期-队列模型进行未来预测，以估计2022年至2035年焦虑障碍的残疾调整生命年趋势。结果：1990年至2021年间，围绝经期妇女焦虑障碍的全球年龄标准化残疾调整生命年率从625.51（95%不确定区间：429.1-891.09）上升至677.15(95%不确定区间：469.45-952.72)，呈上升趋势，估计平均百分比变化为0.081（95%可信区间：0.0043-0.143）。注意到地区差异，焦虑障碍负担在不同社会人口指数水平的地区有所不同。预测表明，到2035年，全球围绝经期妇女焦虑症负担将上升至每10万人中有1180.43人，比2021年的水平增加40.67%。结论：围绝经期焦虑症的负担日益受到全球关注，预计未来几年将显著增加。迫切需要有针对性的预防和干预策略来减轻这一日益增加的负担，并改善围绝经期的心理健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.40

自引率

4.00%

发文量

444

审稿时长

>12 weeks

期刊介绍： BMC Women''s Health is an open access, peer-reviewed journal that considers articles on all aspects of the health and wellbeing of adolescent girls and women, with a particular focus on the physical, mental, and emotional health of women in developed and developing nations. The journal welcomes submissions on women''s public health issues, health behaviours, breast cancer, gynecological diseases, mental health and health promotion.