Exploring Natural Analgesics for Chronic Pain Management: Cannabinoids and Other Phytoconstituents.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2025-01-06 DOI:10.2174/0109298673330732241017135054

Geir Bjørklund, Oleksandra Oleshchuk, Tetiana Gontova, Mykola Klantsa, Mariana Lukanyuk, Olha Denefil, Оleh Koshovyi, Volodymyr Shanaida, Mariia Shanaida

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Abstract

Chronic pain lasting more than three months or persisting after normal healing is a significant global health issue. In a healthcare system, it is crucial to ensure proper chronic pain management. Traditional pharmacological and non-pharmacological pain management techniques may not fully meet the requirements of physicians regarding effectiveness and safety. Therefore, researchers are exploring natural analgesics. Plant-based phytoconstituents show promise in relieving chronic pain associated with various diseases. This study aims to review the latest advances in discovering natural bioactive compounds that can help alleviate chronic pain. It discusses the pathways of chronic pain and a multifactorial treatment strategy. It also organizes data on using plant- derived substances, such as cannabinoids, terpenoids, phenolics, and crude extracts. Additionally, it delves into the pharmacodynamics of cannabinoids, including their route of administration and elimination. The review presents the results of 22 clinical trials on various cannabinoids for pain relief. It is important to note that opioids and other alkaloids from plants are not covered in this article due to their primary use in controlling acute rather than chronic pain.

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探索慢性疼痛管理的天然镇痛药：大麻素和其他植物成分。

慢性疼痛持续三个月以上或在正常愈合后持续存在是一个重大的全球健康问题。在医疗保健系统中，确保适当的慢性疼痛管理是至关重要的。传统的药理学和非药理学疼痛管理技术可能不能完全满足医生对有效性和安全性的要求。因此，研究人员正在探索天然镇痛药。以植物为基础的植物成分在缓解与各种疾病相关的慢性疼痛方面显示出希望。本研究旨在回顾发现有助于减轻慢性疼痛的天然生物活性化合物的最新进展。它讨论了慢性疼痛的途径和多因素治疗策略。它还组织了使用植物衍生物质的数据，如大麻素、萜类、酚类和粗提取物。此外，它还深入研究了大麻素的药效学，包括它们的给药和消除途径。综述了22项不同大麻素缓解疼痛的临床试验结果。值得注意的是，由于阿片类药物和其他植物生物碱的主要用途是控制急性疼痛，而不是慢性疼痛，因此本文不涉及阿片类药物和其他植物生物碱。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.