{"title":"Diterpenoids from the bark of Torreya grandis and their cytotoxicity activity.","authors":"Yu-Fan Meng, Jing-Jing Yuan, Mao-Sheng Zhang, Da-Le Guo, Pan-Xiang Cao, Jian-Wen Yang, Min-Jian Dong, Jun Dai, Cheng-Xin Sun, Shi-Ji Xiao","doi":"10.1016/j.fitote.2025.106376","DOIUrl":null,"url":null,"abstract":"<p><p>Four previously undescribed diterpenoids (2-5) were isolated from the bark of Torreya grandis, along with ten known analogues. The structures of the compounds were elucidated using NMR, HR-ESIMS, and ECD calculation. The cytotoxic effects of the isolated compounds on HCT-116, AsPC-1, and HepG2 cells were evaluated using the MTT assay. Compound 6 exhibited significant cytotoxicity against HepG2 cells. Further experiments revealed that compound 6 could arrest the G2 phase process in HepG2 cells through the JAK2/STAT3 signaling pathway.</p>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"181 ","pages":"106376"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.fitote.2025.106376","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Four previously undescribed diterpenoids (2-5) were isolated from the bark of Torreya grandis, along with ten known analogues. The structures of the compounds were elucidated using NMR, HR-ESIMS, and ECD calculation. The cytotoxic effects of the isolated compounds on HCT-116, AsPC-1, and HepG2 cells were evaluated using the MTT assay. Compound 6 exhibited significant cytotoxicity against HepG2 cells. Further experiments revealed that compound 6 could arrest the G2 phase process in HepG2 cells through the JAK2/STAT3 signaling pathway.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
